Endotracheal Intubation Clinical Trial
Official title:
Cerebral NIRS Profiles During Premedication for Neonatal Intubation
Observational ancillary study of the PRETTINEO study (ClinicalTrials.gov Identifier:
NCT01490580) which is a multicenter double blind randomized controlled trial comparing
"atropine+propofol" vs "atropine+atracurium+sufentanil" as a premedication prior to
endotracheal intubation of the neonate.
Primary outcome:
- Cerebral desaturation defined by a rScO2 delta >20% from the baseline value (before
premedication).
- Variation of more than 10% of cerebral FTOE (Fractional Tissue Oxygen Extraction) during
premedication, calculated from rScO2 and pulse oximetry with the formula FTOE=SaO2 -
rScO2/SaO2 .
Hypothesis: "atropine + propofol" compared to "atropine+atracurium+sufentanil" does not
increase the frequency of cerebral hypoxemia.
n/a
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