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Cerebral Perfusion Pressure Using Precedex and Other Sedatives — C3PO  

Endotracheal Intubation Clinical Trial

Official title:
Cerebral Perfusion Pressure Using Precedex and Other Sedatives

Clinical Trial Summary

The purpose of this study is to examine the effects of using dexmedetomidine (Precedex) in addition to the current standard-of-care for sedation.

Clinical Trial Description

Primarily, this study seeks to explore whether there is a difference in mean arterial pressure (MAP) variability, incidence of intracranial hypertension, intracranial pressure (ICP) variability, cerebral perfusion pressure (CPP) and Cerebrovascular pressure reactivity index (PRx) in two groups of subjects.

Patients must be submitted to the ICU and be endotracheally intubated and receiving mechanical ventilation with continuous IV sedation for less than 24 hours after recruitment into the study. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01169467
Study type Interventional
Source Duke University
Contact
Status Completed
Phase Phase 3
Start date October 2009
Completion date November 2013
View Details
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