Prematurity; Extreme Clinical Trial
Official title:
Risk of Chronic Diseases in Young Adults Born Preterm: Relationship With Inflammation and Oxidative Stress Biomarkers.
Verified date | November 2022 |
Source | St. Justine's Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
The purpose of the HAPI project is to study the overall health of preterm infants once they reach adulthood. The investigators would like to compare the health of adults born preterm with that of adults born full-term. They would also like to find the early signs, or biomarkers, of chronic diseases such as high blood pressure, diabetes, osteoporosis, and chronic lung diseases. Such biomarkers would allow for early diagnosis and prevention. Furthermore, the investigators would like to understand why some people born preterm are more likely to develop chronic disease. They believe that inflammation and oxidative stress may play a part. Oxidative stress is present when the body is not able to defend itself against oxygen-derived products that can damage our cells. To carry out this study, the investigators will examine 6 aspects of the health: (1) heart and circulation, (2) kidneys, (3) lungs, (4) metabolism - sugars and fats in the blood, (5) bones, and (6) eyes.
Status | Completed |
Enrollment | 200 |
Est. completion date | April 29, 2017 |
Est. primary completion date | March 29, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 29 Years |
Eligibility | Inclusion Criteria: EPT : - Birth at GA<29 wks - Age 18-29 years at the time of assessment (age of peak human physiological function) Terms: - Birth at GA =37 wks - Born in Quebec, to account for health care access during pregnancy and throughout infancy/childhood - Birth date within 2 years of index case - Age 18-29 years at the time of assessment - Same self-reported race as preterm participant. Exclusion Criteria: Both groups : - Currently pregnant due to X-ray related risks - Severe neurosensory deficit preventing test completion. - In case of twins (or +), if both fulfil inclusion criteria, only one will selected (random) to participate to the study |
Country | Name | City | State |
---|---|---|---|
Canada | StJustine's Hospital | Montréal | Quebec |
Lead Sponsor | Collaborator |
---|---|
St. Justine's Hospital | Jewish General Hospital, McGill University Health Centre/Research Institute of the McGill University Health Centre |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Markers of inflammation | Blood samples for measurements of biomarkers of inflammation are collected in the morning the day of the visit. Monocyte chemoattractant-1 (pg/mL), Interleukine-6 (pg/mL), tumor necrosis factor-alpha (pg/mL), intercellular adhesion molecule-1 (pg/mL), vascular cell adhesion molecule-1 (pg/mL), high-sensitivity C-reactive protein (pg/mL). | 1 hour | |
Primary | Markers of oxydative stress in the blood | Blood samples for measurements of biomarkers of oxidative stress are collected in the morning the day of the visit. Blood : Glutathione (GSH and GSSG (nmol/mg of proteins)) and Redox potential using the Nernst equation and the values of GSH and GSSG (mV). | 1 hour | |
Primary | Markers of oxydative stress in the urine | Urine 8-prostaglandin F2-alpha (pg/mL). | 1 hour | |
Primary | Markers of oxydative stress in the plasma | Oxidized LDL (U/L) | 1 hour | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: blood pressure | Blood pressure (mmHg) | 1 hour | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: Cardiac structure and function by echocardiography- LV hypertrophy #1 | Cardiac structure and function by echocardiography. Left ventricle hypertrophy determined by the LV mass (g) indexed to body surface area (BSA in m2) giving a unit of g/m2. | 30 min | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: Cardiac structure and function by echocardiography- LV hypertrophy #2 | Cardiac structure and function by echocardiography. Left ventricle hypertrophy determined by the interventricular septum thickness (cm). | 30 min | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: Cardiac structure and function by echocardiography -LV hypertrophy #3 | Cardiac structure and function by echocardiography. Left ventricle hypertrophy determined by LV dysfunction (%) or by endocardial fractional shortening (%) | 30 min | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: Arterial structure and function by ultrasound. | Arterial structure and function (mm) will be measured using a Dopller ultrasound. | 1 hour | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: Adiposity measures #1 | Body mass index in kg/m2, calculating using the weight in kg and the height in m | 15 min | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: Adiposity measures #2 | Using lean and fat body (g) m | 30 min | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: glucose homeostasis | Plasma fasting glucose (mmol/L) and insulin (mmol/L) and different times after a 75 g of glucose load. | 2 hours | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: Fasting lipid profile | Plasma triglycerides (mmol/L), HDL (mmol/L) and LDL (mmol/L). | 1 hour | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: kidneys functions #1 | Urinary protein excretion (albumin/creatinine ratio, mg/mmol), eGFR cystatin C (cystatin C : mg/L) (mL/min/1.73 m2). The formula use the cystatin C values in mg/mL, the standardized serum cystatin min and max, the age (in years) and the sex (female: 0.932, male : 1). | 30 min | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: kidneys functions #2 | Use of the eGFR cystatin C formula (cystatin C : mg/L) (mL/min/1.73 m2). The formula use the cystatin C values in mg/mL, the standardized serum cystatin min and max, the age (in years) and the sex (female: 0.932, male : 1). | 15 min | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: pulmonary functions #1 | FEV (%) | 30 min | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: pulmonary functions #2 | Airflow obstruction (FEV1/FVC ratio, no units). | 30 min | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: Questionnaires #1 | Determinants of health. Questionnaires about socio-economics status, family history, personal medical history. | 2 hours | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: Questionnaires #2 | Determinants of health. Maternal obstetrical and subjects neonatal history. | 2 hours | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: Questionnaires #3 | Determinants of health. Health-related behaviors | 2 hours | |
Secondary | CVD risk factors and indicators of (sub)clinical disease: Questionnaires #4 | Determinants of health. Food frequency questionnaire | 2 hours |
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