Infertility Clinical Trial
Official title:
The Flexible GnRH Antagonist Protocol Provides Better Results (IVF Outcomes) Than Flare up GnRH Agonist Protocol in Poor Responders
The purpose of this study is to compare ovulation induction using a flexible GnRH antagonist protocol and flare up GnRH agonist protocol in IVF patients with poor response to ovarian stimulation. Our hypothesis is that the antagonist protocol provides better IVF outcomes compared to the flare up protocol in this group of patients.
Poor responders are women who fail to respond effectively to the usual gonadotropin
stimulation protocol applied in an IVF cycle. It seems that a diminished ovarian reserve is
the principal factor of poor ovarian response. Several strategies have been proposed for the
management of poor responders, including flare up GnRH agonist regimens and the GnRH
antagonist, which presents a new hope in this group of patients.
Comparisons: Poor responder patients (see inclusion criteria) commencing an IVF treatment
cyle will receive ovarian stimulation treatment either using a GnRH antagonist (Ganirelix)
or flare up agonist (Arvekap) protocol. Primary outcomes compared will be ongoing pregnancy
rates in the two treatment groups.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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