Premature Birth Clinical Trial
Official title:
Wales Electronic Cohort for Children (WECC)
The investigators are developing a research platform capable of improving children's health
through the generation of knowledge from analysis of routinely collected data from within
and outside the health service.
The investigators are using the data that are routinely collected in Wales to answer
specific questions about child health and well-being, with the aim of informing policy and
practice in Wales, whilst also being internationally relevant.
Routinely collected datasets are publicly funded, and have already been incorporated into
the Secure Anonymised Information Linkage databank. The investigators are combining these
datasets on children from health and social care to establish an anonymised Wales wide
Electronic Cohort for Children (WECC). WECC will serve as the platform for future work in
translating information into child population health policy.
There are 35,000 births in Wales per year, and data are available for the previous ten
years. Thus, WECC will be sufficiently powered to answer important social, economic and
health policy questions. WECC will also act as a demonstration project which would inform
the development of e-cohorts to support translational research across the life course and
disease spectrum.
Lack of access to the enormous amount of information collected on children's health status
and treatment has been a major contributor to both gaps in the translational pathway to
improving child health at individual and population levels. The creation of the Wales
Electronic Child Cohort is designed to remove this block and support both explanatory and
interventional studies. This proposal is considered to be the best way to address this issue
as it is built upon previous strategic investments by WORD and thus should achieve its goals
in a very cost effective manner.
This type of E-Cohort with 35,000 additional children every year can answer questions where
exposures, outcomes and potential confounders are routinely collected or available through
individual or ecological linkages. This is a retrospective and prospective cohort, however,
both cohort and nested case-control studies can be supported. Developments in geographical
information systems (GIS), network analysis and the creation of a system for anonymising
households means that is possible to anonymously link environmentally derived data to health
data. The huge numbers of individuals involved in WECC means that the study has enormous
power to answer important social, economic and health policy questions.
Examples of research questions which can be answered are:
1. What factors determine the future health service need for individuals that are
vulnerable at birth, and inform the development of interventions to reduce health
inequalities for these groups?
2. What is the influence of the social and physical environment on childhood obesity?
3. What is the impact of health conditions in childhood on educational outcomes for
children?
4. Are birth anomalies more common in households in which any member received antibiotics
during early pregnancy (marker for infectious cause)?
5. What is the relationship between maternal depression, family composition and childhood
injury risk?
6. Can perinatal environmental and biological parameters be used to predict common illness
such as asthma in later childhood and adults?
7. To what extent can E-Cohorts replicate findings from traditional cohorts (e.g.
Millennium Cohort Study) and replace the need for some non-routine data collection?
In this first instance we will focus on answering the first two questions.
;
Observational Model: Cohort
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT05048550 -
Babies in Glasses; a Feasibility Study.
|
N/A | |
Active, not recruiting |
NCT03655639 -
Local Version of the Multi-center PREVENT Study Evaluating Cardio-respiratory Instability in Premature Infants
|
||
Enrolling by invitation |
NCT05542108 -
Adding Motion to Contact: A New Model for Low-cost Family Centered Very-early Onset Intervention in Very Preterm-born Infants
|
N/A | |
Completed |
NCT03680157 -
Comparing Rater Reliability of Familiar Practitioners to Blinded Coders
|
||
Completed |
NCT03337659 -
A Cluster Randomized Controlled Trial of FICare at 18 Months
|
N/A | |
Completed |
NCT03649932 -
Enteral L Citrulline Supplementation in Preterm Infants - Safety, Efficacy and Dosing
|
Phase 1 | |
Completed |
NCT03251729 -
Cerclage On LOw Risk Singletons: Cervical Cerclage for Prevention of Spontaneous Preterm Birth in Low Risk Singleton Pregnancies With Short Cervix
|
Phase 4 | |
Not yet recruiting |
NCT05039918 -
Neonatal Experience of Social Touch
|
N/A | |
Not yet recruiting |
NCT03418012 -
Prevention of sPTB With Early Cervical Pessary Treatment in Women at High Risk for PTB
|
N/A | |
Not yet recruiting |
NCT03418311 -
Cervical Pessary Treatment for Prevention of s PTB in Twin Pregnancies on Children`s Long-Term Outcome
|
N/A | |
Completed |
NCT02952950 -
Is it Possible to Prolong the Duration of Breastfeeding in Premature Infants? a Prospectivt Study
|
N/A | |
Completed |
NCT02913495 -
Vaginal Versus Intramuscular Progesterone for the Prevention of Recurrent Preterm Birth
|
Phase 4 | |
Not yet recruiting |
NCT02880696 -
Perception of Temporal Regularity in Tactile Stimulation: a Diffuse Correlation Spectroscopy Study in Preterm Neonates
|
N/A | |
Completed |
NCT02661360 -
Effects of Swaddling on Infants During Feeding
|
N/A | |
Completed |
NCT02743572 -
Iron-fortified Parenteral Nutrition in the Prevention and Treatment of Anemia in Premature Infants
|
N/A | |
Completed |
NCT02879799 -
Family Integrated Care (FICare) in Level II NICUs
|
N/A | |
Completed |
NCT01352234 -
Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia
|
Phase 4 | |
Completed |
NCT01163188 -
Social Adjustment and Quality of Life After Very Preterm Birth
|
N/A | |
Terminated |
NCT00675753 -
Three Interacting Single Nucleotide Polymorphisms (SNPs) and the Risk of Preterm Birth in Black Families
|
N/A | |
Completed |
NCT00271115 -
Kangaroo Holding and Maternal Stress
|
N/A |