Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension

Prehypertension Clinical Trial

Official title:

Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06428890
• Other study ID #: 030-2223-EXP
• Status: Completed
• Phase: N/A
• Start date: March 1, 2022
• Est. completion date: April 1, 2024

Study information

• Verified date: May 2024
• Source: California Baptist University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aimed to assess the effect of the supplementation with grape seed extract (GSE) on blood pressure during static handgrip exercise and muscle metaboreflex in individuals with elevated and state 1 hypertension.

Description:

Muscle metatoreflex (MMR) has been known to play an important role in adjusting hemodynamic responses during exercise. The reflex increases sympathetic activity to heart and blood vessels to increase blood supply to contracting skeletal muscles. On the other hand, studies demonstrated that abnormal cardiovascular responses occurred by the overactive MMR in pathological conditions such as hypertension, diabetes, and congestive heart failure. Excessive blood pressure (BP) responses to exercise induce cardiovascular events such as stroke, heart attack, and coronary artery disease. Previously, a study found that dietary supplementation with grape seed extract (GSE) reduced BP response to dynamic exercise in individuals with elevated and stage 1 hypertension (ES1H) and associated with peripheral vasodilation. However, mechanisms underlying this phenomenon are not clear. Purpose: therefore, the purpose of this study is to investigate whether chronic dietary supplementation with GSE can decrease BP responses to exercise and this observation is associated with reduced MMR. Methods: 12 ES1H males were studied. Changes in cardiac output (Q), mean arterial pressure (MAP) and total peripheral resistance (TPR) were compared between the GSE and placebo supplementations during static handgrip exercise (SHE) and post exercise muscular ischemia (PEMI). Participants completed 3 min of SHE at 40% of MVC followed by 2 min of PEMI.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: April 1, 2024
• Est. primary completion date: April 1, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• systolic blood pressure: 120-139 mmHg and/or a diastolic blood pressure: 80-89 mmHg

Exclusion Criteria:

• taking medications that could affect cardiovascular function or BP

Related Conditions & MeSH terms

• Hypertension
• Prehypertension

Intervention

Dietary Supplement:
• Grape Seed Extract
dietary supplements that rich in polyphenolic compounds
• Placebo
Starch

Locations

Country	Name	City	State
United States	California Baptist University	Riverside	California

Sponsors (1)

Lead Sponsor	Collaborator
California Baptist University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	heart rate (bpm)	measured these variables at rest and during static handgrip exercise and muscle metaboreflex	5 minutes, 3 minutes, and 2 minutes, respectively.
Primary	stroke volume (ml)	measured these variables at rest and during static handgrip exercise and muscle metaboreflex	5 minutes, 3 minutes, and 2 minutes, respectively.
Primary	cardiac output (l/min)	measured these variables at rest and during static handgrip exercise and muscle metaboreflex	5 minutes, 3 minutes, and 2 minutes, respectively.
Primary	systolic blood pressure (mmHg)	measured these variables at rest and during static handgrip exercise and muscle metaboreflex	5 minutes, 3 minutes, and 2 minutes, respectively.
Primary	diastolic blood pressure (mmHg)	measured these variables at rest and during static handgrip exercise and muscle metaboreflex	5 minutes, 3 minutes, and 2 minutes, respectively.
Primary	total peripheral resistance (mmHg/l/min)	measured these variables at rest and during static handgrip exercise and muscle metaboreflex	5 minutes, 3 minutes, and 2 minutes, respectively.