Prehypertension Clinical Trial
Official title:
Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension
This study aimed to assess the effect of the supplementation with grape seed extract (GSE) on blood pressure during static handgrip exercise and muscle metaboreflex in individuals with elevated and state 1 hypertension.
Muscle metatoreflex (MMR) has been known to play an important role in adjusting hemodynamic responses during exercise. The reflex increases sympathetic activity to heart and blood vessels to increase blood supply to contracting skeletal muscles. On the other hand, studies demonstrated that abnormal cardiovascular responses occurred by the overactive MMR in pathological conditions such as hypertension, diabetes, and congestive heart failure. Excessive blood pressure (BP) responses to exercise induce cardiovascular events such as stroke, heart attack, and coronary artery disease. Previously, a study found that dietary supplementation with grape seed extract (GSE) reduced BP response to dynamic exercise in individuals with elevated and stage 1 hypertension (ES1H) and associated with peripheral vasodilation. However, mechanisms underlying this phenomenon are not clear. Purpose: therefore, the purpose of this study is to investigate whether chronic dietary supplementation with GSE can decrease BP responses to exercise and this observation is associated with reduced MMR. Methods: 12 ES1H males were studied. Changes in cardiac output (Q), mean arterial pressure (MAP) and total peripheral resistance (TPR) were compared between the GSE and placebo supplementations during static handgrip exercise (SHE) and post exercise muscular ischemia (PEMI). Participants completed 3 min of SHE at 40% of MVC followed by 2 min of PEMI. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03644524 -
Heat Therapy and Cardiometabolic Health in Obese Women
|
N/A | |
Completed |
NCT02551640 -
Improving Physical Activity Through a mHealth Intervention in Cardio-metabolic Risk Patients
|
N/A | |
Recruiting |
NCT01483430 -
Effect of Ginseol Kg1 on Blood Pressure Lowering
|
Phase 3 | |
Terminated |
NCT01295216 -
Use of Mobile Technology to Prevent Progression of Pre-hypertension in Latin American Urban Settings
|
N/A | |
Completed |
NCT01637909 -
Korean Life-Style Modification Effects on Blood Pressure
|
N/A | |
Unknown status |
NCT01308983 -
Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension
|
Phase 4 | |
Active, not recruiting |
NCT03596099 -
Rice Vinegar as an Intervention to Lower Blood Pressure in Adults With Prehypertension and 10-year CVD Risk <10%
|
N/A | |
Completed |
NCT04326686 -
Measuring Individual Responses to a Wholegrains and Nuts Intervention to Reduce Blood Pressure in Prehypertension
|
N/A | |
Completed |
NCT03898518 -
The Effects of a Jump Rope Exercise Program on Body Composition and Self-efficacy in Obese Adolescent Girls
|
N/A | |
Terminated |
NCT01983462 -
Vascular Dysfunction in Human Obesity Hypertension
|
Phase 2 | |
Completed |
NCT01458496 -
Health Coaching to Effect Lifestyle Behaviour Change
|
N/A | |
Completed |
NCT01472692 -
Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure
|
Phase 4 | |
Completed |
NCT03266510 -
Inspiratory Muscle Strength Training to Improve Blood Pressure and Physiological Function
|
N/A | |
Completed |
NCT02998840 -
A Prospective Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure
|
Phase 2 | |
Completed |
NCT01974570 -
Effect and Safety of Marealis RPC (Refined Peptide Concentrate) in Mild or Moderate Hypertensive Subjects
|
Phase 2 | |
Completed |
NCT02326766 -
Blood Pressure Lowering Effect of Supplementation With Korea Red Ginseng Associated With Reductions in Circulating Lp-PLA2 Activity and Lysophospatidylcholines and an Increase in Dihydrobiopterin in Prehypertensive Subjects
|
Phase 3 | |
Completed |
NCT01395329 -
Nebivolol and the Endothelin (ET)-1 System
|
Phase 4 | |
Completed |
NCT01331486 -
Nitric Oxide Mediated Vasodilatory Response to Hawthorn Standardized Extract
|
Phase 1 | |
Completed |
NCT05274971 -
Diet and Exercise on Ambulatory Blood Pressure
|
N/A | |
Active, not recruiting |
NCT02371317 -
Stress Management for High Blood Pressure
|
N/A |