Clinical Trials Logo
  1. Home
  2. Pregnant Women
  3. NCT05358834

Testing Effects of Melatonin on Uterine Contractions in Women — MelPreg  

Pregnant Women Clinical Trial

Official title:
Testing Effects of Melatonin on Uterine Contractions in Women

Clinical Trial Summary

The study will extend recent discoveries that have been made in basic human physiology related to responses melatonin and uterine contractions in late- or full-term pregnant women. The basic physiology work has been conducted in in vitro models of the human myometrium characterizing its responses to melatonin, and in pilot in vivo studies correlating the number of uterine contractions with melatonin concentrations that were manipulated by different types of light exposure. The planned experiments will test a causal link between circulating melatonin levels and uterine contractions in full-term pregnant women by manipulating melatonin levels using exogenous melatonin (i) during the day when endogenous levels of melatonin are very low (Experiment 1), and (ii) during the evening under conditions with lighting that would be expected to suppress the higher evening and nighttime levels of endogenous melatonin (Experiment 2).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05358834
Study type Interventional
Source Brigham and Women's Hospital
Contact Elizabeth B Klerman, MD PhD
Phone 617-643-2424
Email ebklerman@hms.harvard.edu
Status Recruiting
Phase N/A
Start date January 1, 2023
Completion date June 30, 2027
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT03955263 - Malaria In Pregnancy in Central India
Not yet recruiting NCT04457947 - Exploring Aromatherapy Intervention in Acute Care
Active, not recruiting NCT01397318 - Effects of Modified TaiChi Exercise on Maternal Stress, Fatigue, Sleep Quality, Biomarkers, and Infant Gestational Age and Birthweight N/A
Completed NCT00639145 - Elizabeth Glaser Pediatric AIDS Foundation Maternal Events and Pregnancy Outcomes (MEP Project)A Multi-site Protocol
Not yet recruiting NCT00931099 - Fetal Outcome of Sleep Disordered Breathing During Pregnancy N/A
Recruiting NCT00751569 - microRNA Profile in Umbilical Cord Blood NK Cells N/A
Completed NCT06111716 - Mindfulness in Childbirth Preparation Education Process N/A
Completed NCT05729191 - Evaluation of the Acceptance of the Anti-COVID-19 Vaccine Offer Among Pregnant Women
Completed NCT01687634 - Home Visiting for Low Income, Pregnant Women N/A
Recruiting NCT05446571 - Prenatal Treatment of Congenital Cytomegalovirus Infection With Letermovir Versus Valaciclovir Phase 3
Not yet recruiting NCT03651934 - Verification of Correlation Between Genetic Testing of Nutritional Metabolism and Clinical Biochemical Indicators N/A
Active, not recruiting NCT06422130 - Ningbo Maternity-Child Linked Database Study
Completed NCT03538106 - Factors Associated With Cesarean Delivery in Women With Type 1 Diabetes
Completed NCT02904473 - Goals for Reaching Optimum Wellness (GROWell) N/A
Recruiting NCT01246765 - National Pregnancy Registry for Psychiatric Medications
Completed NCT00553228 - Pertussis Maternal Immunization Study Phase 2/Phase 3
Recruiting NCT05916534 - We Care About Brooklyn - A Digital Behavioral Intervention to Optimize Engagement in Maternal Healthcare N/A
Completed NCT04264910 - CALM Pregnancy: Feasibility of Calm for Pregnant Women N/A
Completed NCT04494581 - GriCoVax Study in 4 Maternity Wards in the Ile-de-France Region
Recruiting NCT05349279 - Qatar PREgnancy Covid-19 OUtcome Study