Ningbo Maternity-Child Linked Database Study

Status Active, not recruiting

Clinical Trial Summary

With the implementation of China's two-child policy and a marked increase in adverse pregnancy outcomes, leveraging electronic health records (EHR) to enhance maternal and child healthcare and outcomes in China has emerged as a novel strategy to tackle this pivotal demographic and health challenge. Given the mature construction of the information platform and the well-established maternal and child health service system in Ningbo, this study utilized the Ningbo Maternal and Child Health Electronic Monitoring Information Management System and the Ningbo Regional Health Information Platform to conduct the Ningbo maternity-child linked database study (MATCHLESS), which involved over 300,000 mother-child pairs in China. MATCHLESS not only allows for longitudinal follow-up of pregnant women and their offspring but also expands its scope from prenatal exposure to long-term outcomes through data linkage. The longitudinal scope of MATCHLESS facilitates the elucidation of the relationship and etiological significance of early-life exposures and adverse pregnancy outcomes. It also permits the exploration of the health trajectory of women and children over their life-course. During the past 5 years (October 2016 to December 2021), a substantial amount of maternal and child health data has been recorded in MATCHLESS, including socio-demographics, health care services and medications, as well as clinical outcome events. Additionally, it contains longitudinal measurements on risk factors for adverse pregnancy outcomes, which provides a robust foundation for future real-world studies of dynamic predictive models. This study was approved by the Ethics Review Committee of the Ningbo University Health Science Center. Considering the safety, privacy, and confidentiality concerns surrounding the storage and processing of personal EHR data, the responsibility for data storage and management is undertaken by the Health Commission of Ningbo. Researchers are required to submit applications to the local health department, and all studies undergo ethical review and research registration procedures to access EHR data for health research purposes.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06422130
Study type	Observational [Patient Registry]
Source	Ningbo University
Contact
Status	Active, not recruiting
Phase
Start date	October 1, 2016
Completion date	December 31, 2026

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03563196` - Diagnosis Of Pulmonary Complications After Cardiac Surgery In Children
Completed	`NCT02553486` - Internationally Adopted Children Quality of Life	N/A
Completed	`NCT02903134` - Early Risk of Asthma in Children Exposed to In-utero Maternal Obesity
Completed	`NCT02918890` - Intensive Unimanual (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegia	N/A
Active, not recruiting	`NCT01874847` - PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin	Phase 2/Phase 3
Enrolling by invitation	`NCT01971827` - Effectiveness of a Physical Activity Intervention to Prevent Obesity and Improve Academic Performance	N/A
Enrolling by invitation	`NCT01971840` - Effectiveness of a Physical Activity Intervention on Preventing Obesity During the Adiposity Rebound Period.	N/A
Completed	`NCT01738308` - The Effects of Healing Touch on Post Operative Pediatric Patients	N/A
Completed	`NCT01693926` - Effect of Physical Activity an Stress in Children	N/A
Completed	`NCT01864811` - Effect of Baby-CIMT in Infants Younger Than 12 Months	N/A
Completed	`NCT01943760` - Tamadol Wound Infiltration in Children Under Inguinal Hernioplasty	Phase 4
Completed	`NCT01323010` - Efficacy and Safety of Increasing Doses of Inhaled Albuterol in Children With Acute Wheezing Episodes	N/A
Completed	`NCT01277224` - Effectiveness of a Physical Activity Intervention on the Obesity of Schoolchildren	N/A
Active, not recruiting	`NCT00989547` - Cord Blood Infusion for Type 1 Diabetes Mellitus (T1DM)	Phase 1
Completed	`NCT04051723` - Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine for Post-Craniotomy Pain in Children	Phase 4
Completed	`NCT03236363` - Effectiveness of MOVI Interventions on Adiposity, Cognition and Motor Competence: MOVI-da10!	N/A
Completed	`NCT03236337` - Effectiveness of MOVI Interventions on Adiposity, Cognition and Subclinical Atherosclerosis: MOVI-daFit!	N/A
Not yet recruiting	`NCT03427697` - Effect of VR and Accommdation Relax on Controlling Myopia in Children	N/A
Completed	`NCT05603507` - Inspiratory Muscle Training in Children With Chest Burn	N/A
Not yet recruiting	`NCT06267339` - Effects of Transcranial Random Noise Stimulation on Motor Learning in Typically Developing Adolescents	Early Phase 1

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Ningbo Maternity-Child Linked Database Study — MATCHLESS

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms