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Influence of Sex Hormones Variation During Third Trimester of Pregnancy and Post-partum on QT Interval Duration — QuTe  

Pregnancy Clinical Trial

Official title:
Influence of Sex Hormones Variation During Third Trimester of Pregnancy and Post-partum on QT Interval Duration

Clinical Trial Summary

QT interval prolongation, corrected for heart rate (QTc), either spontaneous or drug-induced, is associated with an increased risk of torsades de pointes and sudden death. Women are at higher risk of torsades de pointes, particularly during post-partum and the follicular phase. The aim of this study is to explore if QTc duration is prolonged during post-partum as compared to the 3rd trimester of pregnancy

Clinical Trial Description

Sex steroid hormones are known to influence heart repolarization. Overall, estradiol is considered to promote QTc lengthening while progesterone and testosterone shorten QTc. New findings suggest more complex regulation of QTc by sex steroid hormones involving also follicle-stimulating hormone, which is associated to prolongation of QTc. Another important aim of this study is to study the influence of sex hormones on QTc duration. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02931695
Study type Interventional
Source French Cardiology Society
Contact
Status Completed
Phase N/A
Start date April 24, 2017
Completion date October 24, 2023
View Details
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