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Study of the Effect of Beta-3 Adrenergic Receptor Agonists on Oxidative Stress and Signalling Pathways Implicated in Remodelling of the Uteroplacental Space: Experimental in Vitro Approach on Myometrial Tissue Explants — STRESSOX  

Pregnancy Clinical Trial

Official title:
Study of the Effect of Beta-3 Adrenergic Receptor Agonists on Oxidative Stress and Signalling Pathways Implicated in Remodelling of the Uteroplacental Space: Experimental in Vitro Approach on Myometrial Tissue Explants

Clinical Trial Summary

CHRONOLOGICAL DESCRIPTION OF THE STUDY

1. Information provided to study participants

2. Collection of written informed consent

3. Harvesting of myometrial biopsies

4. Creation of tissue explants using myometrial biopsies

5. Stimulation of the explants with LPS

6. Study of the effect of SAR150640 (beta3-adrenergic agonist) on LPS-induced oxidative stress Moreover, demonstrating the ability of beta3-adrenergic receptor agonists to prevent the appearance of oxidative stress and its consequences on tissues, as a complement to previous studies, is an additional argument for the clinical development of this class of pharmaceuticals in the management of threatened premature delivery and labour induction.

Clinical Trial Description

n/a

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02862886
Study type Interventional
Source Centre Hospitalier Universitaire Dijon
Contact
Status Completed
Phase N/A
Start date July 2010
View Details
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