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Retinal Nerve Fiber Layer and Macular Thickness Changes During Pregnancy

Pregnancy Clinical Trial

Official title:
Retinal Nerve Fiber Layer and Macular Thickness Changes During Pregnancy by Optical Coherence Tomography: Prospective, Observational, Nonrandomized Controlled Study

Clinical Trial Summary

Purpose:

Primary: to prospectively measure Retinal Nerve Fiber Layer (RNFL) and macular thickness changes during pregnancy by Optical coherence tomography

Secondary: The effect of pregnancy abnormalities on RNFL and macular thickness in participants who develop systemic or ocular complications during the study period.

Clinical Trial Description

There are several known ophthalmic physiologic changes in pregnancy:

1. Refractive Change: progesterone-mediated changes in fluid content partially accounts for refractive change of lens and cornea; myopic shift of less than 1 D was observed in in 15% of participating pregnant women

2. Night vision decreased mainly with low serum vitamin A levels in pregnant women.

3. Fall of the IOP in second half of pregnancy (about 10% drop)

4. Corneal changes (increased thickness; decreased sensitivity) = contact lens intolerance

The retina and optic nerve are considered part of central nervous system, the retina and choroid are highly vascularized. Due to changes in CSF and brain volume, vascular and fluid changes all over the pregnant woman's body we expect to find changes in RNFL and macular thickness during pregnancy. ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02154945
Study type Observational
Source The Baruch Padeh Medical Center, Poriya
Contact
Status Withdrawn
Phase N/A
Start date January 2016
Completion date January 2016
View Details
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