Pregnancy Clinical Trial
Official title:
Effect of Assisted Hatching on Vitrified Embryo Transfer Clinical Outcome
The objective of study is to assess the possible impact of assisted hatching on the implantation, pregnancy rate and delivery rate after transfer of vitrified-warmed human embryos.
The embryo implantation rate in assisted reproduction procedures is 20%, which leads to a
low clinical pregnancy rate (35%), and even lower live birth rate (25%), per cycle started.
Low embryo quality, poor endometrial receptivity, difficulties during the blastocyst
hatching process are frequently denoted as the main reasons for the low implantation rate in
humans.
The artificial rupture or thinning of the zona pellucida before embryo transfer—assisted
hatching (AH)—has been proposed to foster spontaneous hatching and improve embryo
implantation rates. Despite great effort, the clinical relevance of AH remains controversial
and elusive.
There is a great importance of AH during frozen embryo cycles. Due to previous studies there
is no precise answer about the value of AH performed on cryopreserved-thawed embryos. As far
as is known, there is no clinical data to indicate the effects of AH on vitrified-warmed
embryo transfer.
The objective of this prospective study is to assess the possible impact of assisted
hatching on the implantation, pregnancy rate and delivery rate after transfer of
vitrified-warmed human embryos.
Eligibility criteria: women age 18-42, cleavage-stage embryo transfer, less than seven IVF
cycles with fresh embryo transfer, high quality embryos.
Procedure: mechanical Assisted Hatching
Primary Outcome: delivery rate Secondary Outcome: implantation rate, pregnancy rate and
delivery rate.
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