Pregnancy Clinical Trial
Official title:
Effect of Assisted Hatching on Vitrified Embryo Transfer Clinical Outcome
The objective of study is to assess the possible impact of assisted hatching on the implantation, pregnancy rate and delivery rate after transfer of vitrified-warmed human embryos.
The embryo implantation rate in assisted reproduction procedures is 20%, which leads to a
low clinical pregnancy rate (35%), and even lower live birth rate (25%), per cycle started.
Low embryo quality, poor endometrial receptivity, difficulties during the blastocyst
hatching process are frequently denoted as the main reasons for the low implantation rate in
humans.
The artificial rupture or thinning of the zona pellucida before embryo transfer—assisted
hatching (AH)—has been proposed to foster spontaneous hatching and improve embryo
implantation rates. Despite great effort, the clinical relevance of AH remains controversial
and elusive.
There is a great importance of AH during frozen embryo cycles. Due to previous studies there
is no precise answer about the value of AH performed on cryopreserved-thawed embryos. As far
as is known, there is no clinical data to indicate the effects of AH on vitrified-warmed
embryo transfer.
The objective of this prospective study is to assess the possible impact of assisted
hatching on the implantation, pregnancy rate and delivery rate after transfer of
vitrified-warmed human embryos.
Eligibility criteria: women age 18-42, cleavage-stage embryo transfer, less than seven IVF
cycles with fresh embryo transfer, high quality embryos.
Procedure: mechanical Assisted Hatching
Primary Outcome: delivery rate Secondary Outcome: implantation rate, pregnancy rate and
delivery rate.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03442582 -
Afluria Pregnancy Registry
|
||
| Terminated |
NCT02161861 -
Improvement of IVF Fertilization Rates, by the Cyclic Tripeptide FEE - Prospective Randomized Study
|
N/A | |
| Not yet recruiting |
NCT05934318 -
L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE)
|
N/A | |
| Enrolling by invitation |
NCT05415371 -
Persistent Poverty Counties Pregnant Women With Medicaid
|
N/A | |
| Completed |
NCT04548102 -
Effects of Fetal Movement Counting on Maternal and Fetal Outcome Among High Risk Pregnant Woman
|
N/A | |
| Completed |
NCT03218956 -
Protein Requirement During Lactation
|
N/A | |
| Completed |
NCT02191605 -
Computer-delivered Screening & Brief Intervention for Marijuana Use in Pregnancy
|
N/A | |
| Completed |
NCT02223637 -
Meningococcal Quadrivalent CRM-197 Conjugate Vaccine Pregnancy Registry
|
||
| Recruiting |
NCT06049953 -
Maternal And Infant Antipsychotic Study
|
||
| Completed |
NCT02577536 -
PregSource: Crowdsourcing to Understand Pregnancy
|
||
| Not yet recruiting |
NCT06336434 -
CREATE - Cabotegravir & Rilpivirine Antiretroviral Therapy in Pregnancy
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT04786587 -
Alcohol Self-reporting During Pregnancy. AUTOQUEST Study.
|
||
| Not yet recruiting |
NCT05412238 -
Formulation and Evaluation of the Efficacy of Macro- and Micronutrient Sachets on Pregnant Mothers and Children Aged 6-60 Months
|
N/A | |
| Not yet recruiting |
NCT05028387 -
Telemedicine Medical Abortion Service Using the "No-test" Protocol in Ukraine and Uzbekistan.
|
||
| Completed |
NCT02683005 -
Study of Hepatitis C Treatment During Pregnancy
|
Phase 1 | |
| Completed |
NCT02783170 -
Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women
|
Phase 4 | |
| Recruiting |
NCT02507180 -
Safely Ruling Out Deep Vein Thrombosis in Pregnancy With the LEFt Clinical Decision Rule and D-Dimer
|
||
| Recruiting |
NCT02564250 -
Maternal Metabolism and Pregnancy Outcomes in Obese Pregnant Women
|
N/A | |
| Recruiting |
NCT02619188 -
Nutritional Markers in Normal and Hyperemesis Pregnancies
|
N/A | |
| Terminated |
NCT02546193 -
Outpatient Foley Catheter Compared to Usual Inpatient Care for Labor Induction
|
N/A |