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NCT03562715 Clinical Trial

microRNAs Role in Pre-eclampsia Diagnosis

Preeclampsia Clinical Trial

Official title:
Role of Mesenchymal Stem Cells Exosomes Derived microRNAs; miR-136, miR-494 and miR-495 in Pre-eclampsia Diagnosis and Evaluation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03562715
Other study ID # BC (1870)
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 28, 2016
Est. completion date December 25, 2017

Study information
Verified date June 2018
Source Cairo University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Pre-eclampsia is one of the most threatening pregnancy complications. So far neither a secure, competent therapy for PE nor effective biomarkers for a premature discovery has been achieved.The aim of our study was to identify miRNAs 136, 494 and 495 genes expression in exosomes of peripheral blood compared to umbilical cord mesenchymal stem cells conditioned media released exososomes in patients with PE, as valuable markers for PE early prediction.

Recruitment information / eligibility
Status Completed
Enrollment 200
Est. completion date December 25, 2017
Est. primary completion date June 15, 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 23 Years to 35 Years
Eligibility Inclusion Criteria:

To have an uncomplicated pregnancy:

1. gestational age at venipuncture between 20 - 42 weeks

2. no medical, obstetrical, or surgical complications

3. absence of labor at the time of venipuncture

4. delivery of a normal term (= 37 weeks) neonate whose birth weight was between the 10th and 90th percentile for gestational age

Exclusion Criteria:

Patients with chronic hypertension, renal disease, and fetuses affected with congenital anomalies were excluded

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Cairo University

Outcome
Type Measure Description Time frame Safety issue
Primary The expression of miRNAs 136, 494 and 495 in exosomes of peripheral blood and UCMSCs conditioned media 2-3 months
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