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NCT00468663 Clinical Trial

Ambient Air Pollution, Preeclampsia, and Preterm Delivery

Preeclampsia Clinical Trial

Official title:
Ambient Air Pollution, Preeclampsia, and Preterm Delivery

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00468663
Other study ID # 14716-CP-001
Secondary ID
Status Completed
Phase N/A
First received May 2, 2007
Last updated April 13, 2015
Start date July 2006
Est. completion date May 2009

Study information
Verified date April 2015
Source National Institute of Environmental Health Sciences (NIEHS)
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

An epidemiologic study of pregnant women in western Washington to measure the relationships between exposure to air pollutants and risks of preeclampsia and preterm delivery.

Description:

We will design models that use local traffic, weather, and population characteristics to predict monthly ambient concentrations of fine particulate matter (PM2.5) and carbon monoxide (CO). These models will be used to estimate study participants' PM2.5 and CO exposures during and before pregnancy. We will test whether these air pollutant exposures are associated with subsequent risk of preeclampsia and preterm delivery. Additionally, we will test biological markers of maternal lipid peroxidation (thiobarbituric acid reactive substances) and inflammation (high sensitivity C-reactive protein) in maternal blood samples drawn during early pregnancy. We will also examine carboxyhemoglobin measured in early-pregnancy maternal blood samples as a marker of CO exposure.

Recruitment information / eligibility
Status Completed
Enrollment 4200
Est. completion date May 2009
Est. primary completion date May 2009
Accepts healthy volunteers
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- English speaking

- enrolled in parent study

- pregnant at <20 weeks gestation and attending prenatal care clinics affiliated with Swedish Medical Center and Tacoma General Hospital

Exclusion Criteria:

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
National Institute of Environmental Health Sciences (NIEHS)
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