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Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia

Preeclampsia Clinical Trial

Official title:
Cardiovascular Performance and Autonomic Reactivity in Formerly Preeclamptic Women With a Contracted Plasma Volume (CAPACITY Trial)

Clinical Trial Summary

A history of preeclampsia is associated with a low plasma volume and higher sympathetic activity. Methyldopa will suppress sympathetic activity to normal values. In this study, the researchers will test that effect on the total cardiovascular balance.

Clinical Trial Description

This is a randomized double-blind placebo controlled cross-over study in formerly preeclamptic women with a contracted plasma volume. The researchers will test the effect of methyldopa on the cardiovascular balance and orthostatic tolerance in women with a history of preeclampsia and healthy controls. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00117546
Study type Interventional
Source Radboud University
Contact M.E.A Spaanderman, MD, PhD
Phone +31 24 36 13401
Email m.spaanderman@obgyn.umcn.nl
Status Recruiting
Phase Phase 4
Start date September 2005
Completion date December 2008
View Details
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