Predictors and Outcomes of Meropenem Treatment Failure Clinical Trial
Official title:
Predictors and Outcomes of Meropenem Treatment Failure Among Patients With Septic Shock in Intensive Care Unit
Lately, the inappropriate used of Meropenem in critically ill patient were increased.
Therefore, increased development of drug resistance bacteria towards Meropenem.
As known that Carbapenem-Resistance Enterobacteriaceae (CRE) is part of complication when
Meropenem is widely used in the intensive care unit. CRE are very difficult to treat within
Gram negative bacteria as it encodes Carbapenemase enzyme which breaks down Carbapenem
anti-microbial such as Meropenem. The widespread carbapenemase production in the
Enterobacteriaceae was unknown until the early 2000 until first reported in 2001. Despite
that, most doctors and physician favourite, and still prescribe Meropenem as the antibiotic
of choice for the critically ill patients empirically. This is because of its broad spectrum
of coverage for bacteria. Thus, a number of Meropenem treatment failure were increased as
resistance increase.This study will evaluate the appropriate use of Meropenem and determine
the predictors of Meropenem treatment failure as well as the patient outcomes.As a result, it
can be a guidance prior prescribing the Meropenem base on patient clinical condition and
parameters while balancing the risk and benefits of its used.
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