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Ultrasound to Assess Sarcopenia in Prader Willi Syndrome — PWS  

Metabolic Syndrome Clinical Trial

Official title:
Usefulness of Ultrasound to Assess Sarcopenia in Individuals With Prader Willi Syndrome

Clinical Trial Summary

The aim of the study is to examine the clinical applicability of ultrasound as a diagnostic tool for sarcopenia in individuals with PWS by investigating the association between ultrasound-derived measurements, DXA-derived measurements, and sarcopenia-related outcomes.

Clinical Trial Description

Sarcopenia is an age-related loss of muscle mass plus low muscle strength, and/or low physical performance, that may affect over 25% of individuals over the age of 60, resulting in an increased likelihood of developing disability. Abnormal body composition with an increased in body fat mass and a decreased in skeletal muscle mass were noted in individuals with Prader Willi syndrome (PWS), thought to be related to hormonal deficiencies due to hypothalamic dysfunction, presenting as a unique congenital model of sarcopenia. Muscle mass can be measured by dual-energy X-ray absorptiometry (DXA) scan device, but it is expensive, increased radiation exposure, and not easily accessible in all clinical practice. Ultrasound (USD) is a non-invasive, without ionising radiation, low-cost, and easily accessible tool for the assessment of soft tissue. There were increasing evidence for the use of USD in the measurement of muscle thickness (MT), cross-sectional area (CSA) and pennate anle (PA) of different muscle groups in different populations. However, the use of USD as a routine diagnostic tool in individuals with PWS has not been reported yet. The aim of the study is to examine the clinical applicability of ultrasound as a diagnostic tool for sarcopenia in individuals with PWS by investigating the association between ultrasound-derived measurements, DXA-derived measurements, and sarcopenia-related outcomes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06448871
Study type Observational
Source Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Contact Valeria Chiu, MD
Phone 0982766578
Email haydenbell28@gmail.com
Status Recruiting
Phase
Start date October 17, 2022
Completion date June 30, 2024
View Details
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