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Gut Derived Hormones, Body Composition and Metabolism in Prader-Willi Syndrome

Prader-Willi Syndrome Clinical Trial

Official title:
Contribution of a GLP-1 Agonist to Appetite Regulation, Metabolism and Body Composition in Subjects With Prader-Willi Syndrome.

Clinical Trial Summary

The purpose of this study is to investigate the effects of a GLP-1 agonist on satiety hormones in patients with Prader-Willi Syndrome (genetic defect causing obesity).

Clinical Trial Description

Prader-Willi Syndrome (PWS) is the most frequent known genetic disorder of obesity. Hyperphagia is the main barrier to independent living in adults with PWS, and hitherto behavioural restraints and environmental modification are the only effective management measure. The emerging costs for professional care are immense. Thus, there is an urgent need for treatment which reduce appetite and food intake in this patient group. Agonists of the gut derived hormone GLP-1 which reduces food intake and causes weight loss due to slowed gastric emptying and through direct central effects. The aim of this pilot drug trial is to analyse the effect of a GLP-1 agonist on appetite regulating hormones, insulin secretion and energy expenditure before and after a meal. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00551343
Study type Interventional
Source Garvan Institute of Medical Research
Contact
Status Completed
Phase N/A
Start date October 2007
Completion date September 2008
View Details
See also
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