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Postthrombotic Syndrome clinical trials

View clinical trials related to Postthrombotic Syndrome.

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NCT ID: NCT01578122 Completed - Clinical trials for Deep Vein Thrombosis

Elastic Compression Stockings for Prevention of Post-thrombotic Syndrome

CELEST
Start date: June 29, 2012
Phase: N/A
Study type: Interventional

Post thrombotic syndrome (PTS) is a frequent and burdensome complication of proximal deep-vein thrombosis.Therapeutic options for PTS are limited and mainly rely on its prevention. Therapeutic trials evidenced that elastic compression stockings (ECS) applying 30-40mmHg of pressure at the ankle reduced the rate of PTS by 50%. Although ECS are unlikely to cause harm, in clinical practice, compliance to this treatment appears to be low as ECS may be difficult to apply and to wear. ECS with a lighter compression strength (20-30mmHg) might be easier to apply and be more comfortable. This could favor a better compliance. CELEST is a randomized, multicentre, double-blind trial which aims to determine whether ECS applying 25mmHg of targeted pressure at the ankle are non inferior to ECS applying 35mmHg of targeted pressure at the ankle

NCT ID: NCT01567150 Completed - Clinical trials for Venous Stasis Ulcers

Wound Fluid Protease Levels During Use of Novel Wound Dressing

Start date: February 2012
Phase: Phase 4
Study type: Interventional

This study is being conducted to characterize the way leg wounds respond to a new type of wound dressing, compared to wounds in patients who are not using the new dressing. The investigators will collect wound fluid for biochemical analysis, and they will measure the wound healing that occurs with and without the new dressing.

NCT ID: NCT01482273 Completed - Venous Thrombosis Clinical Trials

Ultrasound-enhanced Thrombolysis Versus Standard Catheter Directed Thrombolysis for Ilio-femoral Deep Vein Thrombosis

BERNUTIFUL
Start date: November 2011
Phase: N/A
Study type: Interventional

Patients with deep vein thrombosis (DVT) of the ilio-femoral veins have increased risk for developing post-thrombotic syndrome (PTS) and recurrent venous thromboembolism compared to more distal DVT. There's evidence that the early removal of the obstructing thrombus by catheter directed thrombolysis (CDT) reduces the risk of developing a PTS, and a higher degree of thrombolysis is associated with lower incidence of PTS, better quality of life and lower risk of recurrent venous thromboembolism. A further development is ultrasound-enhanced thrombolysis combining CDT with a sophisticated catheter system that employs high-frequency, low-dose ultrasound. In vitro experiments showed that adding ultrasound to thrombolytic drugs accelerates thrombolysis while Ultrasound exposure alone results in no thrombolysis, however the superiority of ultrasound-enhanced thrombolysis over standard CDT has never been formally assessed in vivo. The hypothesis for this study is that ultrasound-enhanced thrombolysis reaches a higher degree of thrombolysis than standard CDT in patients with symptomatic ilio-femoral DVT.

NCT ID: NCT01432795 Completed - Clinical trials for Chronic Venous Insufficiency

Practicability of Gliding Aids for Medical Compression Stockings

Start date: November 2010
Phase: Phase 4
Study type: Interventional

Medical compression stockings are highly effective in the prevention, treatment, and secondary prevention of chronic venous insufficiency and of post-thrombotic syndrome. Non-adherence to the prescribed compression treatment concerns approximately 40% of patients. Elderly patients are often unable to handle stockings in order to put them on properly in the morning and to undress in the evening. Gliding aids and stocking "butlers" are two types of tools to facilitate the dressing manoeuvre with medical stockings. The present study evaluates four different gliding aids and two different stocking "butlers" to put on three different types of compression stockings. The study is conducted with forty consenting subjects with advanced chronic venous insufficiency.

NCT ID: NCT01429714 Completed - Clinical trials for Postthrombotic Syndrome

The Ideal Deep Venous Thrombosis (DVT) Study

IDEAL
Start date: March 22, 2011
Phase: N/A
Study type: Interventional

In the Netherlands, 25.000 patients each year are diagnosed with Deep Venous Thrombosis (DVT). Elastic compression stocking (ECS) therapy reduces the incidence of post thrombotic syndrome (PTS) following DVT from 50% without ECS to 20-30% after ECS therapy for two years. It is however unclear whether all patients benefit to the same extent from this therapy or what the optimal duration of ECS therapy for individual patients should be. ECS therapy is not only costly, inconvenient and demanding but sometimes also even debilitating. Substantial costs could be saved by tailoring therapy to individual needs and as a result the quality of life for individual patients can be expected to improve. This study aims to assess the costs and effects of tailoring the duration of ECS therapy after DVT to individual patients needs. ECS therapy with a standard duration of 24 months will be compared with tailored ECS therapy, following an initial therapeutic period of 6 months, in patients with acute proximal DVT. The primary outcome is the percentage of patients with PTS at two year follow-up. This is a multi-center, randomized, allocation concealed, single-blinded clinical trial.

NCT ID: NCT01129986 Completed - Clinical trials for Venous Stasis Ulcers

A Post Marketing Clinical Study Utilizing DermaStream and Saline in Venous Ulcers

Start date: June 2009
Phase: N/A
Study type: Interventional

An open-label, prospective, controlled, two-step approach, post-marketing clinical study, applying DermaStream with saline streaming, in conjunction with a sustained multi-compression wrap, on healthy individuals and on patients with a venous stasis ulcer of the lower extremity.

NCT ID: NCT00910364 Completed - Clinical trials for Deep Vein Thrombosis

Feasibility Study of Exercise in Patients With Leg Blood Clots

EXPERT
Start date: October 2008
Phase: N/A
Study type: Interventional

The purpose of this pilot study is to assess the feasibility of determining the effects of a structured exercise program started two to four weeks after diagnosis of a first episode lower-extremity deep vein thrombosis (DVT) for a period of 12 weeks in reducing the incidence of post-thrombotic syndrome (PTS).

NCT ID: NCT00900029 Completed - Venous Leg Ulcer Clinical Trials

Safety Follow-Up to HP 802-247-09-015

Start date: June 2009
Phase: N/A
Study type: Observational

The objective of this study is to examine the durability of previous target wound closures, identify new test article-related adverse events, record new target wound closures, and examine ongoing adverse events not resolved in subjects who participated in HP 802-247-09-015.

NCT ID: NCT00858130 Completed - Clinical trials for Deep Vein Thrombosis

Pilot Study for VeinoPlus to Improve Symptoms of Postthrombotic Syndrome (PTS)

VeinoPlus
Start date: March 2009
Phase: N/A
Study type: Interventional

The investigators plan to perform an exploratory study to investigate the effects of electro-stimulation of the legs on the symptoms and clinical findings of post thrombotic syndrome (PTS), as well as quality of life of patients with PTS. The investigators theorize that electro-stimulation will provide both a mechanical benefit via muscular contraction and increased venous outflow from the affected extremity, as well as an anesthetic effect, which the investigators anticipate will translate into improved symptomatic outcomes, quality of life (QOL) benefits.

NCT ID: NCT00852995 Completed - Venous Leg Ulcer Clinical Trials

Dose Finding Study of HP802-247 in Venous Leg Ulcers

Start date: February 2009
Phase: Phase 2
Study type: Interventional

This is a 16-week study for subjects with a venous leg ulcer between the knee and ankle. This research is being done to determine the effectiveness of two dosing frequencies and two different concentrations of HP802-247, together with standard care, compared to placebo, plus standard care.