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Postpartum Endometritis clinical trials

View clinical trials related to Postpartum Endometritis.

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NCT ID: NCT05603624 Terminated - Chorioamnionitis Clinical Trials

Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term

Start date: September 2, 2021
Phase: N/A
Study type: Interventional

This prospective randomized controlled study examines whether the type of glove used (sterile vs clean) for cervical examination to assess progression in labor impacts the rates of intrapartum and/or postpartum infection in patients during labor or induction of labor at term.

NCT ID: NCT05118984 Completed - Clinical trials for Postpartum Endometritis

Efficacy of Azithromycin in MSAF Cases to Improve Maternal and Neonatal Outcomes

Start date: February 16, 2021
Phase: Phase 4
Study type: Interventional

Meconium stained amniotic fluid increases the risk of maternal complications (e.g., dystocia, operative delivery, and postpartum endometritis) and neonatal complications (e.g., sepsis, admission to the neonatal intensive care unit [NICU], and meconium aspiration syndrome). The goal of the study is to compare between Azithromycin vs Placebo in cases of meconium stained amniotic fluid during the first stage of labor in multigravida women and their effect on maternal and neonatal outcomes.

NCT ID: NCT04385680 Completed - Wound Infection Clinical Trials

Chlorhexidine Vaginal Preparation for Reduction of Post-cesarean Endometritis and Sepsis

Start date: May 15, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

The study aims to assess the beneficial value of vaginal preparation with chlorhexidine gluconate 0.05% before cesarean delivery of cases in labor in reduction of postoperative endometritis, fever and wound complications compared to no preparation or using saline only.

NCT ID: NCT03840889 Not yet recruiting - Clinical trials for Postpartum Hemorrhage

Secondary Postpartum Hemorrhage

SPPH
Start date: March 1, 2019
Phase:
Study type: Observational

Postpartum hemorrhage (PPH) remains one of the leading causes of maternal mortality and morbidity worldwide, including in France, where it accounts for approximately 20% of maternal mortality. Although numerous studies have examined immediate PPH, very few have explored secondary (also called late) PPH. Moreover, there are no guidelines in France for the management of secondary PPH. Its frequency appears to vary from 0.2% to 3.0% of deliveries. It is, however, difficult to estimate because only severe secondary PPH will lead to hospitalization and the rare publications concern single-center studies. The cause of these secondary hemorrhages is often unknown, due to the lack of routine uterine aspiration. Nonetheless, this aspiration is not always medically justified. The principal objective of this study is thus to establish the incidence of severe late PPH in the general population.

NCT ID: NCT03478163 Terminated - Clinical trials for Postpartum Hemorrhage

Antibiotics During Intrauterine Balloon Tamponade Placement

Start date: March 8, 2018
Phase: Phase 4
Study type: Interventional

The goal of this study is to identify whether antibiotics given at the time of placement of an intrauterine balloon tamponade (IBT) will result in reduction of the risk of endometritis. The investigators hypothesize that antibiotics given at the time of intrauterine balloon tamponade will reduce the likelihood of postpartum endometritis.

NCT ID: NCT03248297 Completed - Clinical trials for Postpartum Endometritis

Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries

Start date: January 12, 2018
Phase: Phase 4
Study type: Interventional

This study, performed over a course of 3 years in 5 collaborating hospitals in Cameroon, Africa, will randomize 750 women in labor with prolonged rupture of membranes ≥ 8 hours or prolonged labor ≥ 18 hours to identical oral regimens of 1 gram of azithromycin, 1 gram of azithromycin+2 grams of amoxicillin or placebo. Women will be followed to ascertain maternal infectious outcomes and perinatal outcomes.

NCT ID: NCT01437228 Completed - Clinical trials for Postpartum Endometritis

Does Preoperative Vaginal Preparation With Povidone-iodine Before Cesarean Delivery Reduce the Risk of Endometritis?

Start date: October 2010
Phase: Phase 4
Study type: Interventional

Cesarean delivery rates are increasing in Turkey and a major component of this increase is cesarean on demand. Although data on the rate of cesarean delivery in Turkey is limited, a national study reported a rate of 23.8%. Infectious morbidity, consisting primarily of endomyometritis and wound infection, remains a leading cause of postoperative complications. Estimates of postcesarean infection rates range from 7% to 20%, depending on demographic and obstetric variables. Infection following cesarean delivery results in not only increased hospital stay but also increases the cost of care. Strategies to minimize postoperative infectious and other morbidities have included modifications of surgical technique, changing of gloves, methods of placental delivery, cervical dilatation during cesarean delivery, and altering the uterine position during repair of the uterine incision. Despite these interventions, endometritis is still major problem after cesarean delivery. Endometritis appears to result from ascending vaginal flora bacteria, with anaerobes playing an important role. The microbes endogenous to the vagina change throughout the course of pregnancy and parturition. Larsen and Galask noted that anaerobic species located in the vagina increase dramatically by the third postpartum day. In many cases, the surgeon's hand, reaching below the infant's head or presenting part, is in direct contact with the vagina. Vaginal bacterial flora have been cultured from the delivering surgeon's glove in 79% (95% confidence interval [CI] 58%, 100%) of cesareans that follow labor. In these cases, vaginal flora are delivered directly to the uterus, abdominal cavity, and the abdominal incision. Vaginal preparation has been shown to decrease the quantitative load of vaginal microorganisms as well as to remove certain species of bacteria.