Flurbiprofen Axetil as an Adjuvant to Pre-emptive Scalp Infiltration

Status Recruiting

Clinical Trial Summary

Post-craniotomy pain remains a major challenge in patient care following neurosurgery.Flurbiprofen axetil (FA), as an injectable nonselective cyclooxygenase inhibitor, is a widely prescribed NSAID for postoperative pain. As FA is highly lipophilic by merging into emulsified lipid microspheres, it has a high affinity to the surgical incision and inflammatory tissues to achieve targeted drug therapy and prolonged duration of action, thus providing a basis for its local use to achieve efficacy and safety comparable to or greater than systemic administration. In this study, we attempt to evaluate the clinical effects of FA as an adjunct to ropivacaine in pre-emptive scalp infiltration to prevent or reduce pain after craniotomy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05624359
Study type	Interventional
Source	Beijing Tiantan Hospital
Contact	Fang Luo, Doctor
Phone	86-13611326978
Email	13611326978@163.com
Status	Recruiting
Phase	N/A
Start date	November 1, 2023
Completion date	July 1, 2024

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