Clinical Trial Details
— Status: Active, not recruiting
Administrative data
NCT number |
NCT05379192 |
Other study ID # |
farukcicekci5 |
Secondary ID |
|
Status |
Active, not recruiting |
Phase |
|
First received |
|
Last updated |
|
Start date |
January 1, 2022 |
Est. completion date |
December 31, 2022 |
Study information
Verified date |
May 2022 |
Source |
Selcuk University |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational [Patient Registry]
|
Clinical Trial Summary
These circadian rhythms are self-sustained, endogenous oscillations generated by circadian
clocks that persist with a period of around 24 -h under constant conditions. Multiple
clinical and foundational science studies report that circadian rhythm disruption can
directly alter pain thresholds. Altered circadian pain rhythms manifest inconsistently in
various disease states. circadian differences exist in tolerability of administration as well
as in effectiveness of analgesia during surgical, obstetric, and dental procedures, with the
majority of studies demonstrating highest pain sensitivity during the overnight or early
morning hours. Although the relationship between pain states and circadian rhythm has been
studied in various surgical procedures and chronic pain syndromes, there is little literature
examining the relationship between postoperative pain and circadian rhythm in pediatric
surgical procedures. Therefore, it was aimed to evaluate the relationship between
postoperative pain and circadian rhythm after pediatric acute appendicitis surgery.
Description:
This study will be conducted with the data to be obtained from the Anesthesiology Surgery
Form and Pediatric Surgery Service Forms in 200 patients aged 6-18 years, after the approval
of the Faculty Local Ethics Committee in the Department of Anesthesiology, Faculty of
Medicine, Selcuk University. According to the time the patients were taken into the
operation, Group 1; 01:01-07:00, Group 2; 07:01-13:00, Group 3; 13:01-20:00 and Group 4;
20:01-01:00, It will be divided into four groups between. The files of the patients will be
examined and demographic data such as age (year), body weight (kg), height (cm), gender, ASA
scores (I-III), anesthesia and surgery time, anesthesia and surgery time will be recorded.
Intraoperative vital signs; systolic arterial pressure (SAP), diastolic arterial pressure
(DAP), mean arterial pressure (MAP), heart rate (HR) oxygen saturation (SpO2) Endtidal CO2
and temperature before operation (control) and 5, 10, 15, 20, 25 and 30 minutes (min) and at
the end of the process (end) data will also be saved. Perioperative side effects such as
nausea-vomiting, hypotension, bradycardia, tremor, respiratory distress, sore throat,
headache, and dizziness symptoms will be noted if they occur. The routinely applied analgesic
protocol and vital signs in the postoperative pediatric surgery service, the total amount of
analgesic administered, the time to first analgesia requirement and VAS scores at 1, 2, 3, 6,
9, 12, 15, 18, 21 and 24th hours will also be recorded. There will be no interference with
the routinely applied analgesic protocol.