Postoperative Pain Clinical Trial
Official title:
Impact of Placement of a Diazepam Suppository Intraoperatively on Early Postoperative Pain Following Pelvic Reconstructive Surgery: a Double-Blind, Randomized Placebo-Controlled Trial
This is a randomized double-blinded placebo controlled trial to examine the use of rectal diazepam suppositories after major vaginal pelvic organ prolapse surgery will decrease postoperative pain in the interval between 3.5 and 6 hours postoperative compared to placebo.
Hysterectomy is the most common major surgery performed in gynecology. Minimally invasive
techniques for hysterectomy including vaginal and laparoscopic routes are preferred over the
more invasive abdominal procedures, which are associated with more pain, longer hospital
stays, and increased rates of complications.
Research has continued to provide evidence that same day discharge (SDD) after hysterectomy
is safe, cost effective, and well received by patients. Pain is a common concern for patients
undergoing major pelvic surgery and pain must be well controlled prior to discharge home.
Rectal administrations of medications are an attractive option postoperatively in patients
desiring SDD. Rectal analgesia avoids 1st pass metabolism in the liver, leading to increased
bioavailability of many medications and fewer side effects such as nausea and vomiting.
The purpose of the study is to investigate whether perioperative administration of a rectally
administered diazepam suppository results in improved pain scores between 3.5 and 6 hours
postoperatively in patients undergoing major vaginal pelvic reconstructive surgery.
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