Postoperative Pain Clinical Trial
Official title:
Influence of SPI-guided Analgesia With Preventive Different Peribulbar Blocks (PBB) on the Presence of OCR, Postoperative Pain, PONV in Patients Undergoing VRS Under General Anaesthesia: a Randomised, Controlled Trial
The aim of this randomized trial is to assess the efficacy of preventive analgesia using
different peribulbar blocks (PBB) under SPI-guided anaesthesia for vitreoretinal surgery
(VRS), presence of PONV (postoperative nausea and vomiting) and oculocardiac reflex (OCR) and
compare Numerical Rating Scale (NRS) with Surgical Pleth Index (SPI) for monitoring pain
perception postoperatively.
Patients will receive general anaesthesia combined with either preventive PBB using either
lidocaine with bupivacaine or bupivacaine or ropivacaine
Monitoring depth of anaesthesia using spectral entropy (SE) and quality of neuromuscular
block are routine in modern anaesthesia, whereas monitoring of analgesia still requires
further studies. Recently, the Surgical Pleth Index (SPI) was added as a surrogate variable
showing the nociception-antinociception balance into abovementioned parameters constituting a
novel approach in monitoring patients intraoperatively, known as adequacy of anaesthesia
(AoA) or tailor-made anaesthesia.
Different options of local anesthetic mixtures used for peribulbar block result in different
analgetic potency. PBB is supposed to reduce requirement for intraoperative narcotic
analgesics when used together with general anaesthesia and therefore may reduce the rate of
PONV, OCR and perception of postoperative pain.
The aim of the study is to investigate the influence of different PBBs on abovementioned
outcomes.
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