Pain After PRP Revascularization and Endodontic Treatment of Non-vital Mandibular Molars With Apical Periodontitis

Postoperative Pain Clinical Trial

Official title:

Evaluation of Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization Versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars With Chronic Peri-apical Periodontitis

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03350841
• Other study ID #: CEBD-CU-2017-11-27
• Status: Not yet recruiting
• Phase: N/A
• First received: November 16, 2017
• Last updated: November 29, 2017
• Start date: January 2018
• Est. completion date: December 2019

Study information

• Verified date: November 2017
• Source: Cairo University
• Contact: yassmin ahmed
• Phone: 00201006088594
• Email: yassmin.ahmed[@]dentistry.cu.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

randomized clinical trial which Evaluate thr Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars with Chronic Peri-apical Periodontitis

Description:

it will be done in 2 visits where in the firist visit, i will finish cleaning and shaping of the canals and inject double antibiotic paste as intracanal medication.

in the second visit, removal of intracanal medication then obturaton of the canals in the control group. while in the intervention group,over instrumentation of the canals beyond the working length using k-file size 20-35 to establish bleeding in the canals.then blood sample is collected for PRP preparation then injected into the canal.the patient will record post operative pain 6,12,24,48 hours then 3,4,5 days later.then they will do CBCT at 6, 12 months after the treatment to assess peri-apical healing

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 36
• Est. completion date: December 2019
• Est. primary completion date: December 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 15 Years to 35 Years

Eligibility

Inclusion Criteria:

• Medically free patients, between 18-40 years

• Patients with necrotic pulp in mandibular molar permanent teeth with closed apex

Exclusion Criteria:

• Illiterate patient

• Patients with systemic diseases

• Pregnant women

• Patients that have allergy to ciprofloxacin or metronidazole

• Teeth that:

• Have vertical root fracture, coronal perforation, and calcification.

• re-treatment cases

• Non restorable

• Patients that have T.M.J. disorder

Related Conditions & MeSH terms

• Pain, Postoperative
• Periapical Periodontitis
• Periodontitis
• Postoperative Pain

Intervention

Procedure:
• Platelet rich plasma PRP
blood sample is collected to prepare platelet rich plasma injected in the canal
• root canal treatment
conventional root canal treatment and obturation with guttapercha

Locations

Country	Name	City	State
Egypt	Yassmin Elsayed Ahmed	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Post-operative Pain	postoperative pain evaluated using NRS scale It is a numerical rating scale from 0-10 with 0 representing no pain and 10 representing worst pain	5 days
Secondary	healing	healing of periapical tissue evaluated radiographically	12 months