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OFA - Opioid Free Anesthesia — OFA  

Postoperative Pain Clinical Trial

Official title:
Study Protocol "OFA: Opioid-Free Anesthesia".

Clinical Trial Summary

Opioids have been used for analgesia since many years, but despite potent analgesia they are also associated to side effects, including opioid induced Hyperalgesia (OIH).

OIH in the surgical setting is debated, and may predispose patients to higher analgesic consumption in the preoperative period, and peripheral and central sensitization. The aim of the study is to compare remifentanil-based vs non opioid analgesia (clonidine, lidocaine, ketamine) for intraoperative management of patients undergoing laparoscopic left hemicolectomy, with the hypothesis that non- opiod treated patients will have lower morphine consumption in the first 24 hours after surgery. Peripheral and central hyperalgesia will be tested with Von Frey hairs and pin-prick to evaluate acute CNS (Central Nervous System) sensitization after surgery. Acute and persistent (1 and 3 months) pain will be registered, together with any side effect and parameters of surgical rehabilitation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03124082
Study type Interventional
Source University of Parma
Contact Bugada Dario, MD
Phone +390521703567
Email dariobugada@gmail.com
Status Recruiting
Phase Phase 4
Start date January 4, 2017
Completion date March 31, 2018
View Details
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