Postoperative Pain Clinical Trial
Official title:
Effect of Single Intravenous Ketamine Dose on Postoperative Pain Following Cesarean Section Under Spinal Anesthesia: A Randomized Control Clinical Trial.
The purpose of this study is to investigate the analgesic effect of low-dose intravenous ketamine in pregnant mothers undergoing cesarean section under Bupivacaine spinal anesthesia.
- No premedication will be given, and patients will be monitored by electrocardiogram,
non-invasive arterial blood pressure, and pulse oximetry when they entered the
operating room.
- 18 gauge IV cannula will be inserted and all patients will be preloaded with 10 ml/kg
of lactate ringer over 20 min period.
- All participants will have spinal anesthesia using bupivacaine. The dose of the drug,
as well as the method of injection will be identical for all individuals; 10 mg (2 cc
0.5%), in the L4-L5 space using needle 25 G, midline, with the patient in a sitting
position.
- After administering bupivacaine, and prior to surgery the height of the sensory block
will be assessed bilaterally (complete loss of sensation to ice) in a ascending fashion
starting from T12 dermatome.
- Once adequate anesthesia to at least T6 dermatome will be achieved, the operation will
be allowed to begin. When systolic blood pressure decrease to ＜ 90 mmHg, or 30% of the
pre-anesthetic blood pressure, it will be corrected by administering 5 mg ephedrine.
- Patients will be asked to report any intraoperative pain using visual pain score(VPS)of
0(no pain) 10(worst pain).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator), Primary Purpose: Treatment
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