Postoperative Pain Clinical Trial
Official title:
Ultrasound Guided Transversus Abdominalis Plane Block ( TAPB) Versus Quadratus Lumborum Type II Block (QLBII) in Perioperative Analgesia for Kidney Transplantation Procedure: Clinical Randomized Multicenter Study
The main advantage of Quadratus Lumborum Block (QLB) compared to Transversus Abdominalis
Plane Block (TAPB) is the impact on visceral pain due to the spread of the local anaesthetic
agent to the paravertebral space. It may produce extensive analgesia and better pain control.
Previews studies shoved the effectiveness of TAPB in kidney transplantation procedure (KTX)
by reducing opioids requirements during and after the operation. QLB was not evaluating in
KTX procedure yet, but it reduced postoperative morphine requirement after cesarean section
under spinal anaesthesia.
The aim of this prospective, randomised controlled, multicenter, clinical study is to compare
the perioperative analgesic efficacy of QLB and TAPB in patients who had KTX under balanced
(general and regional) anaesthesia.
After Bioethical Committee of Medical University of Warsaw approval, informed written consent
will be obtained from all patients.
A sample size of 104 patients was calculated to obtain at list 25% reduction of fentanyl
usage in QLBII group with 0,05% significance and power of 0,8. Consenting patients, scheduled
to KTX procedure under general anaesthesia will be randomly assigned (1:1) according to the
computer -generated randomization list with permuted blocks (block sizes: 20, 20, 24, 40) to
receive 20ml of 0,25% Bupivacaine with epinephrine ipsilaterally to the operation side in
QLBII or TAPB after the general anaesthesia induction and before the surgery starts. All the
blocks will be performed in the supine patients position, under ultrasound guidance for both
techniques. The correct spread of injectate will be confirmed with ultrasound.
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