Postoperative Pain Clinical Trial
Official title:
A Comparative Study Between Intrathecal Magnesium Sulphate Versus Midazolam Along With Epidural 0.75% Ropivacaine in Combined Spinal Epidural Technique for Preeclampsia Parturients Undergiong Elective Caesarean Section
This study compares whether addition of Magnesium or Midazolam intrathecally to epidurally administered isobaric Ropivacaine improves the quality of blockade, haemodynamics and duration of analgesia post-operatively. 25 parturients were given intrathecal Magnesium and rest of the 25 parturients were given intrathecal Midazolam combined with 0.75% Ropivacaine via epidural route.
Magnesium sulphate and Midazolam have been used in clinical trials as adjuvants to local
anaesthetics via intrathecal and epidural routes and are effective in augmenting the quality
of block and prolonging post-operative analgesia.
Noxious stimulation leads to the release of glutamate and aspartate neuratransmitters which
bind to various sub-classes of excitatory aminoacid, including the NMDA receptor.
Intrathecal magnesium potentiates neuraxial anaesthesia by blocking NMDA receptors with out
causing significant side effects as reported in various studies.
Intrathecal Midazolam produces antinociception at spinal cord-level through benzodiazepine
GABA-A receptor complex which are present abundantly in the lamina 2 of spinal cord.
Midazolam also releases endogenous opioid acting at spinal delta receptors and also enhances
adenosine release which also augments analgesia.
;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
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