Intraoperative TIVA With Propofol on Postoperative Pain and Side Effects After Liver Resection Surgery

Postoperative Pain Clinical Trial

Official title:

Retrospective Study to Investigate Intraoperative TIVA With Propofol on Postoperative Pain and Side Effects After Liver Resection Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02179437
• Other study ID #: UW14-356
• Status: Completed
• Start date: August 1, 2014
• Est. completion date: February 22, 2016

Study information

• Verified date: May 2024
• Source: The University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Postoperative pain can be severe after liver resection surgery. However, postoperative pain management may be difficult for this group of patients. Opioidergic neurotransmission may be altered in cirrhotic patients and selectively increasing receptor affinity for opioids. Large dose of strong opioid may be required to achieve adequate pain control. However, this may not be possible due to the side effect of opioid and liver dysfunction after liver resection.

Propofol is a commonly used anaesthetic with rapid recovery and less side effects and TIVA (total intravenous analgesia) with propofol is a common technique now. The reduction on certain serum pro- inflammatory cytokines may lead to more smooth post- surgical recovery.

Recent case report proved the analgesic effect of propofol infusion. However other animal and clinical studies showed controversial result.

The aim of this retrospective study is to investigate the postoperative analgesic effects and side effects of intraoperative TIVA with propofol in patient undergoing liver resection surgery at Queen Mary Hospital, Hong Kong between 2010 to 2012.

Description:

Retrospective audit.

Anaesthetic records and acute pain service records of patient undergone liver resection surgery between 2010 to 2012 in Queen Mary Hospital would be retrieved from the computer.

Data Collection

1. Demographic data;

2. Types of analgesic techniques;

3. Type of pain relief modalities;

4. Pain score up to 72 hours postoperatively;

5. Postoperative opioid consumption;

6. Incidence of adverse events during APS care;

7. Patients' satisfaction on pain relief.

Data Analysis For summarising analysis, mean or median with standard deviation or interquartile range will be reported. Parametric and non-parametric comparative tests will be used for analysis between/among patients with various characteristics. Kaplan Meier survival analysis and log-rank test will be used for duration of APS use.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 95
• Est. completion date: February 22, 2016
• Est. primary completion date: February 22, 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patient undergone liver resection surgery between 2010 to 2012 in Queen Mary Hospital

Exclusion Criteria:

• Essential data were missing.

• Patient participating in other research projects.

• Changes in postoperative pain management technique.

• Patients could not be assessed post-operatively for pain (i.e. post-operative IPPV)

Related Conditions & MeSH terms

• Pain, Postoperative
• Postoperative Pain

Locations

Country	Name	City	State
China	Department of Anaesthesiology, The University of Hong Kong	Hong Kong	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
The University of Hong Kong

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Analgesic consumption		From postoperative 1 hour to postoperative 72 hour
Primary	Postoperative pain score		From postoperative 1 hour to postoperative 72 hour
Secondary	Adverse event		From postoperative 1 hour to postoperative 72 hour