Postoperative Pain Clinical Trial
Official title:
Effectiveness of Preemptive Use of Pregabalin on Pain Intensity and Postoperative Morphine Consumption After Laparoscopic Colorectal Surgery
The purpose of this study is to evaluate how effective is the preoperative administration of pregabalin 300mg, to attenuate postoperative pain and opioids consumption after laparoscopic colorectal surgery
Laparoscopic colorectal surgery has gained wide acceptance because it is associated with
reduced pain, lower morbidity, faster recovery and a shorter hospital stay. However, the
optimal postoperative pain management method for patients undergoing laparoscopic colorectal
surgery is still under evaluation and most of the recommendations are based on studies
performed in open approach procedures.
Recently, the analgesic effect of pregabalin, as a part of a multimodal analgesia, has been
evaluated in many studies. They have shown that pregabalin may have a role in the post
operative pain management, as an adjunct. Pregabalin is an anticonvulsant and anxiolytic
drug, which have a more favorable pharmacokinetic profile from its predecessor gabapentin.
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