Postoperative Pain Clinical Trial
Official title:
Transdermal Fentanyl Patch for Postoperative Analgesia in Total Knee Arthroplasty
The purpose of this study is to determine whether transdermal fentanyl patch
Total knee arthroplasty (TKA) has severe postoperative pain that prevents mobilization of
patient. The best standard analgesia regimen is patient-control analgesia (PCA) which
requires a PCA pump that is expensive.
Transdermal fentanyl patch (TFP)(50 mcg/hr) can release fentanyl into blood circulation at
rate 50 mcg/hr for three days. It has slow onset of about 12-14 hours, so it's used to treat
chronic pain, not popular for a cure of pain. If the investigators apply TFP at appropriate
times, i.e. 12-14 hours before surgery, it may be used to treat acute postoperative pain.
If it can give good analgesia for TKA, it can replace PCA. The benefit is that it is much
cheaper and more convenient.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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