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Postoperative Pain clinical trials

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NCT ID: NCT04402411 Recruiting - Surgery Clinical Trials

Quadratus Lumborum Block vs Transversus Abdominis Plane Block in Bladder Cancer Surgeries

Start date: June 1, 2020
Phase: N/A
Study type: Interventional

Transversus abdominis plane (TAP) block can be used to provide effective analgesia during the postoperative period following a range of surgeries. TAP block administers local anesthetics between the T6 to L1 spinal nerve roots to stop the nerve signal and to alleviate pain for abdominal procedures 4, 5. The viscera are innervated by the vagal nerve (parasympathetic innervation) and by the splanchnic nerves (sympathetic innervation). The splanchnic nerves carry both visceral efferent and afferent nerve fibers. The sensory (or afferent) part of the splanchnic nerves reach the spinal column at certain spinal segments, It is possible to block central visceral pain conduction with thoracic paravertebral blockade or maybe even with the novel quadratus lumborum (QL) block. The effect of the QL block is believed to result from a spread of LA from its lumbar deposition cranially into the thoracic paravertebral space (TPVS), since Carney et al found traces of contrast agent in the TPVS following application of this block. Hence, the QL block would seem to be able to alleviate both somatic and visceral pain.10 The aim of this study is to compare between quadratus lumborum block, transversus abdominis plane block regarding perioperative analgesia after bladder cancer surgeries by measuring intraoperative hemodynamics, postoperative pain scores and morphine consumption in the first 24 h postoperative.

NCT ID: NCT04314505 Recruiting - Postoperative Pain Clinical Trials

Opioid-Sparing Protocol Comparing With Opioid-based Protocol After Bilateral Total Knee Arthroplasty

Start date: March 20, 2020
Phase: Phase 4
Study type: Interventional

The concern for the opioid use in the total knee arthroplasty continues to rise in recent decades. Historically, the total knee arthroplasty consumed high doses opioids in the postoperative periods. Compared to the Opioid-Based patient controlled analgesia(PCA), the opioid-sparing protocol may have benefits to decrease the concerns of the opioid use and opioid-related complication and provides the equivalent efficacy for pain control. The purpose of this trial in to provide a novel opioid-sparing protocol (OSP) to evaluate the efficacy for pain control and reducing the immediate postoperative opioid consumption.

NCT ID: NCT04309955 Recruiting - Lung Cancer Clinical Trials

Modified Versus Traditional Thoracic Drainage After Thoracoscopic Surgery

Start date: December 1, 2019
Phase: N/A
Study type: Interventional

Lung cancer is the leading cause of cancer-related death worldwide. Thoracoscopic pulmonary resection is a prevalent management for early stage of lung cancer. Placement of traditional chest tube is the standard procedure after surgery, which causes pain that cannot be ignored. We aimed to determine whether a modified thoracic drainage strategy based on pigtail catheter associated with better clinical results compared with traditional methods after thoracoscopic surgery for lung cancer.

NCT ID: NCT04299035 Recruiting - Postoperative Pain Clinical Trials

ESP Block vs. Traditional Pain Management for ERAS

Start date: March 5, 2020
Phase: Phase 3
Study type: Interventional

Patients undergoing thoracotomy, thoracoscopy or other surgical procedures involving the integrity of the chest wall are always in a special point of interest of both surgical and anesthesiological specialities. Most of the patients will describe the pain after thoracic surgery as severe. It might lead to a number of serious complications: respiratory failure due to splinting; inability to clear secretions by effective coughing, with resulting pneumonia; and turning into a chronic pain: the post-thoracotomy pain syndrome. Traditional pain management in these groups of patients — such as opiate treatment, thoracic epidural analgesia, and non-opioid drugs — may have serious side effects. Large doses of opiates suppress the cough reflex and lead to respiratory depression with subsequent re-intubation and re-ventilation. Thoracic epidural analgesia, though being considered paramount among other analgesic options, requires a significant clinical experience. Still, it might be insufficient for satisfactory pain control and even complicated with pneumothorax, total spinal anaesthesia and inadvertent intravascular injection. Non-steroidal anti-inflammatory drugs (NSAIDs) and Tramadol are weak analgesics inadequate for severe pain control and might be responsible for gastrointestinal bleeding. We suggest performing erector spinae plane block for intraoperative and postoperative pain management due to the ease of use and better analgesic effect. What remains is hard proof for the clinical efficacy and safety of this block, followed by a demonstration of the uptake of it in the hands of non-regional anaesthetists.

NCT ID: NCT04290208 Recruiting - Postoperative Pain Clinical Trials

A Comparison of IV Versus PO Acetaminophen Postoperatively for Opioid Consumption After Cesarean Section

Start date: August 22, 2019
Phase: Phase 4
Study type: Interventional

This randomized controlled study will compare narcotic consumption between two groups: patients that receive a perioperative dose of IV acetaminophen versus patients that receive a perioperative dose of oral liquid acetaminophen for scheduled cesarean section.

NCT ID: NCT04250272 Recruiting - Lung Cancer Clinical Trials

Serratus Anterior Plane Block Versus Intercostal Nerve Block for Postoperative Analgesia

Start date: August 16, 2019
Phase: N/A
Study type: Interventional

A prospective randomized controlled study was undertaken to compare the postoperative analgesic effect between ultrasound-guided serratus anterior plane block and intercostal nerve block after video-assisted thoracoscopic lobectomy.

NCT ID: NCT04245280 Recruiting - Postoperative Pain Clinical Trials

Effectiveness of PENG Block Combined to LFCN Block on the Quality of Recovery After Total Hip Replacement

PENG
Start date: May 4, 2021
Phase: N/A
Study type: Interventional

The main objective of this study is to evaluate the effectiveness of the association of PENG and LFCN blocks on the quality of recovery 24 hours after total hip replacement surgery.

NCT ID: NCT04238780 Recruiting - Postoperative Pain Clinical Trials

Erector Spinae Plane Block Reduces Postoperative Pain Following Laparoscopic Colorectal Operation

Start date: February 20, 2020
Phase: N/A
Study type: Interventional

The goal of this study is to evaluate the effect of ultrasound guided erector spinae plane block on postoperative pain and quality of recovery after laparoscopic colon surgery.

NCT ID: NCT04231123 Recruiting - Postoperative Pain Clinical Trials

Pericapsular Nerve Group Block for Elective Hip Arthroplasty

Start date: January 20, 2020
Phase: N/A
Study type: Interventional

This study examine the effect of Pericapsular Nerve Group (PENG) Block on analgesia after elective hip arthroplasty. Half of participants will receive a PENG Block with local anesthetic, while the other half will receive a PENG Block with a placebo.

NCT ID: NCT04228705 Recruiting - Postoperative Pain Clinical Trials

Establishment and Validation of Early-warning Model of Perioperative Pain for the Elders

Start date: December 13, 2019
Phase:
Study type: Observational

This study will collect perioperative pain-related data of elderly patients in multi-centers. Analyzing these collected data to find the high-risk factors of postoperative pain in elderly patients and to establish an early-warning model of perioperative pain in elderly patients, so as to improve the ability of assessing the risks of postoperative pain in elderly patients and providing an early warning.