Transdermal Nicotine and Melatonin Patches for Postoperative Pain Relief

Postoperative Pain Relief Clinical Trial

Official title: Comparative Study Between Transdermal Nicotine and Melatonin Patches on Postoperative Pain Relief After Laparoscopic Cholecystectomy, a Double-blind, Placebo-controlled Trial

Status Completed

Clinical Trial Summary

Sixty female non-smoker patients, aged 18-50 years and ASA I and II undergoing elective laparoscopic cholecystectomy under general anesthesia were included in this randomized controlled double-blind study. Patients were randomly divided into 3 groups 20 each, C group patients received transdermal placebo patch, TDN group (15 mg/16 h) and TDM group (7 mg/8h). Assessment of postoperative pain, sedation, hemodynamic variables such as HR and MAP, postoperative monitoring of arterial SpO2 and side effects (e.g. nausea, vomiting, pruritis, respiratory depression and hemodynamic instability) were done 30 minutes, 1, 2, 6 and 12 hours postoperatively. Postoperative Patient's and Surgeons' satisfaction, Intraoperative bleeding and plasma cortisol (µg / dl) 2 hours postoperatively were also assessed.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Pain, Postoperative
• Postoperative Pain Relief

• NCT number: NCT02747628
• Study type: Interventional
• Source: Ain Shams University
• Status: Completed
• Phase: Phase 4
• Start date: April 2013
• Completion date: July 2015