Postoperative Pain Management Clinical Trial
Official title:
Effect of Intravenous Lidocaine on Postoperative Pain Management After Laparoscopy Cholecystectomy
This study was to evaluate the effect of intraoperative intravenous lidocaine on postoperative pain management after laparoscopic cholecystectomy. Half of patients will receive intravenous lidocaine during procedure, the rest half of patients will receive regular anesthesia care and placebo treatment.
Postoperative pain and ileus are primary reasons for delayed patient recovery and longer
hospital stays after abdominal surgery. Opioids have been widely used to treat pain in this
patient population. However, opioid administration can exacerbate postoperative ileus and
further delay patient recovery. Multimodal approaches and adjunctive therapies are therefore
recommended for pain control after abdominal surgery to reduce opioid consumption and
opioid-related adverse effects.
Studies have reported that systemically administered lidocaine has analgesic,
anti-inflammatory, and anti-hyperalgesic effects. Several clinical trials have been
published that evaluated systemically administered lidocaine for postoperative pain
management and recovery after surgery. However, the evidence for beneficial effects of
systemic lidocaine for postoperative recovery remains controversial. Therefore, the
investigators performed this study to evaluate the efficacy of systemic administration of
lidocaine for postoperative analgesia and gastrointestinal recovery after laparoscopic
cholecystectomy. The investigators primary hypothesis is that systemic lidocaine
administration reduces pain intensity following surgery.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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