Reversal of Remimazolam by a Single Dose of Flumazenil

Status Completed

Clinical Trial Summary

Remimazolam, a brand-new sedative which has benzodiazepine property. It is an ultra-short acting sedative and regarded as a proper drug for procedural sedation.

Clinical Trial Description

As ambulatory surgery has been increased last two decades, 'Enhanced Recovery After Surgery (ERAS)' also has become an important issue in clinical fields. It is very critical that managing postoperative pain, postoperative nausea and vomiting (PONV) and rapid recovery with less complication or side effect to anesthesiologists. Even though remimazolam considered as an ultra-short acting sedative, it shows a relatively longer recovery time than propofol. Fortunately, remimazolam has its own antidote, called 'flimazenil'. With flumazenil, the time to recovery of consciousness dramatically reduces. Common side effects of flumazenil include headache, dizziness, nausea, vomiting, flushing, sweating and injection pain. In this trial we would like to demonstrate that routine single dose of flumazenil could be administered as an antidote of remimazolam without complications or side effects in gynecologic ambulatory surgery. ;

Study Design

Related Conditions & MeSH terms

Ambulatory Surgery
Postoperative Nausea
Postoperative Nausea and Vomiting
Remimazolam

Clinical Trial Details

NCT number	NCT05382806
Study type	Interventional
Source	Konkuk University Medical Center
Contact
Status	Completed
Phase	N/A
Start date	August 2, 2022
Completion date	May 13, 2023

View Details

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