The Effect of Glycyrrhizin on the Occurrence of Postoperative Nausea and Vomiting

Postoperative Nausea Clinical Trial

Official title:

The Effect of Administration of Glycyrrhizin During Induction Period on the Occurrence of Postoperative Nausea and Vomiting After Breast Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04742660
• Other study ID #: KUH
• Status: Completed
• Phase: N/A
• Start date: May 11, 2021
• Est. completion date: March 10, 2022

Study information

• Verified date: May 2022
• Source: Konkuk University Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators investigate the association between the administration of glycyrrhizin during induction of general anesthesia and the occurrence of postoperative nausea and vomiting (PONV) in patients undergo breast surgery

Description:

Postoperative nausea and vomiting (PONV) is one of a common complication after general anesthesia with 30-50% of incidence, increased up to 80% in high risk group. The risk factors of PONV include women population, the previous history of PONV, motion sickness in usual life, non-smoker, exposure to inhalants, perioperative opioid and laparoscopic surgery. Women population is a strong risk factor of PONV. Although perioperative management of PONV based on a guideline has been done in a lot of medical centers worldwide, the incidence of PONV is still reported relatively high.

The main ingredient of Glycyrrhizin is liquorice which has been used as antispasmodics, antiemetics or treatment for gastric ulcer in oriental medicine. Utilizing these effects of liquorice, the investigators investigate whether the addition of glycyrrhzin to conventional antiemetics is effective to decrease the incidence of PONV and improvement of severity of PONV.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 224
• Est. completion date: March 10, 2022
• Est. primary completion date: March 8, 2022
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• participants scheduled to undergo breast surgery aged 20 and above

Exclusion Criteria:

• aldosteronism

• electrolyte imbalance

• myopathies

• drug addiction or suspected

• bowel disease

• allergy to drugs

• smoker

• taking any medications

Related Conditions & MeSH terms

• Nausea
• Postoperative Nausea
• Postoperative Nausea and Vomiting
• Vomiting

Intervention

Drug:
• Ammonium Glycyrrhizinate
In control group, we assess the incidence and severity of PONV when participants are aministered ramosetron and placebo. In intervention group, the outcomes are assessed as a result of administration of ramosetron and glycyrrhizin.

Locations

Country	Name	City	State
Korea, Republic of	Konkuk University Medical Center	Seoul	Seoul-T'ukpyolshi

Sponsors (1)

Lead Sponsor	Collaborator
Konkuk University Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the incidence of postoperative nausea and vomiting (PONV)	assessing the incidence of postoperative nausea and vomiting with ordinal scale (0=none, 1=nausea, 2=retching, 3= vomiting)	up to 24 hours after discharge from postanesthetic care unit (PACU)