Postoperative Nausea and Vomiting Clinical Trial
Official title:
Effects of Penehyclidine on Postoperative Nausea and Vomiting in Patients Underging Bimaxillary Surgery: A Retrospective Cohort Study
Postoperative nausea and vomiting (PONV) are common complications after surgery. Patients undergoing orthognathic surgery are reported to have a high rate of PONV, especially those undergoing bimaxillary surgery. Activation of cholinergic system plays an important role in the development of PONV. Penehyclidine is an muscarinic antagonists which selectively block M1 and M3 receptors and is commonly used to decrease oral secretion. The purpose of this retrospective cohort study is to investigate whether use of penehyclidine is associated with a reduced risk of PONV in patients undergoing bimaxillary surgery.
Postoperative nausea and vomiting (PONV) are one of the most frequent complications after
surgery, and are associated with patients' dissatisfaction after anesthesia and surgery.
Orthognathic surgery is widely performed for the correction of dentofacial deformities. PONV
is common after orthognathic surgery. Despite of improved anti-emetic prophylaxis, patients
undergoing orthognathic surgery are reported to have a high incidence of PONV, especially
those after bimaxillary surgery.
It is known that activation of central cholinergic system plays an important role in the
development of PONV. Muscarinic antagonists such as scopolamine can block muscarinic
receptors in the cerebral cortex and produce anti-emetic effects. Penehyclidine is a new
muscarinic antagonists which selectively block M1 and M3 receptors. It has fewer adverse
effects compared with other anticholinergics. The purpose of this retrospective cohort study
is to investigate whether use of penehyclidine is associated with a reduce risk of PONV in
patients undergoing bimaxillary surgery.
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