Postoperative Cognitive Dysfunction Clinical Trial
Official title:
Evaluation of the Effect of Intravenous Anesthesia Versus Volatile Anesthesia on Blood-brain Barrier Permeability and Neuroinflammation Affecting Postoperative Cognitive Dysfunction in Elderly Patients: A Randomized Controlled Trial
The goal of this clinical trial is to compare the permeability of blood-brain barrier between the intravenous anesthesia group and the inhalation gas anesthesia group in the elderly patients undergoing surgery. The main questions it aims to answer are: - [Is the permeability of blood-brain barrier between the intravenous anesthesia group and the inhalation gas anesthesia group in the elderly patients different?] - [Is the incidence of postoperative cognitive dysfunction between the intravenous anesthesia group and the inhalation gas anesthesia group different?] Participants will be anesthetized with different categories of anesthetics. - Intravenous anesthetics - Inhalation gas anesthetics
This clinical trial targets patients aged 60 years or older with American Society of Anesthesiologists physical status (ASA) 1 to 3 who undergo surgery under general anesthesia at our hospital. Before entering the operating room, patients are randomly assigned to the intravenous anesthesia group and the inhalation gas anesthesia group. The intravenous anesthesia group uses propofol for anesthesia, and the inhalation gas anesthesia group uses sevoflurane. A 3 mL blood sample is collected four times: before surgery, at the end of surgery, 4 hours after surgery, and 1st day after surgery. All blood samples will be immediately transferred to the department of Laboratory medicine and stored at -80 degree. Pre-scheduled tests to determine the brain-blood barrier permeability and inflammatory cytokines will be conducted after the recruitment of all samples. In addition, for patients scheduled to be transferred to the intensive care unit (ICU) after surgery among the study subjects, a 3 mL of cerebrospinal fluid sample is collected two times: before surgery, and at the end of surgery. The same preservation protocol will be applied to the cerebrospinal fluid samples. All study subjects will be monitored for postoperative delirium daily for up to 7 days after surgery or until discharge. Cognitive function is assessed using telephone version of the Montreal Cognitive Assessment (T-MOCA) before surgery and 3 months after surgery. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05990790 -
The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium
|
Phase 4 | |
| Terminated |
NCT03337282 -
Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients
|
||
| Active, not recruiting |
NCT02965235 -
Correlations of Epigenetic Changes With POCD in Surgical Patients
|
N/A | |
| Not yet recruiting |
NCT02224443 -
Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients
|
Phase 4 | |
| Recruiting |
NCT01934049 -
Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty
|
Phase 4 | |
| Terminated |
NCT00991328 -
Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery
|
Phase 3 | |
| Terminated |
NCT00757913 -
n-3 Enriched Nutrition Therapy and Postoperative Cognitive Dysfunction After Cardiac Surgery
|
Phase 4 | |
| Terminated |
NCT00455143 -
Cognitive Protection - Dexmedetomidine and Cognitive Reserve
|
Phase 4 | |
| Recruiting |
NCT06176144 -
Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients
|
N/A | |
| Completed |
NCT03620968 -
Implementation of a Cognitive Training Program to Reduce the Risk of Postoperative Cognitive Dysfunction
|
N/A | |
| Completed |
NCT04701801 -
Correlation of Preoperative Anxiety With Early Postoperative Cognitive Dysfunction in Breast Cancer Patients
|
||
| Not yet recruiting |
NCT06469515 -
Older People's Neurocognitive Recovery After Cardiac Surgery
|
||
| Completed |
NCT02931877 -
Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia
|
Phase 4 | |
| Not yet recruiting |
NCT02909413 -
Comparison of Desflurane With Sevoflurane for School-age Children in Postoperative Cognitive Function
|
N/A | |
| Completed |
NCT02650687 -
Optimizing Postoperative Cognition the Elderly
|
||
| Not yet recruiting |
NCT01622452 -
Post Cardiac Surgery Neurocognitive Decline: Correlations Between Neuropsychological Tests and Functional MRI Techniques
|
N/A | |
| Completed |
NCT01103752 -
Postoperative Cognitive Dysfunction After Total Knee or Hip Replacement Surgery in Fast-track Set-up
|
N/A | |
| Completed |
NCT04312516 -
Greek Validation of ACE III Test in Perioperative Patients
|
||
| Not yet recruiting |
NCT05668559 -
Transcranial Magnetic Stimulation and Perioperative Neurocognitive Disorders
|
N/A | |
| Not yet recruiting |
NCT05439707 -
Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on POD, POCD and CPSP
|
N/A |