Postoperative Cognitive Dysfunction Clinical Trial
Official title:
Optimization of Desflurane in Elderly Patients Compared With Sevoflurane: A Pilot Study
Various issues had been pointed out when undergoing the anesthesia for elderly patients with
sevoflurane, such as delayed emergence, post-operative trouble with swallowing.
Desflurane, which has a lower blood/gas partition coefficient, is expected to contribute the
better emergence, along with the recent progress on optimization of delivered amount of
anesthesia.
The purpose of this study is to compare the time to emergence in long elderly patient cases
with desflurane or sevoflurane, with the recently developed drug-delivery optimization
system "Aisys®" (GE Healthcare Japan).
The objectives of this study is to compare the time to emergence and quality of recovery in
long elderly patient cases with desflurane or sevoflurane, with the recently developed
drug-delivery optimization system "Aisys®" (GE Healthcare Japan).
Inclusion Criteria:
- Elderly patients (>= 65 yr-old), long operation (> 4hours), abdominal surgery patients
Exclusion Criteria:
- Liver dysfunction, Renal dysfunction, preoperative dementia Neurosurgery patients, Cardiac
surgery patients, obese patients(BMI>35)
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
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