Postoperative Chronic Pain Clinical Trial
Official title:
Effect of Metformin on Chronic Pain After Thoracic Surgery in Diabetic Patients
Metformin has been found to have more and more functions as a commonly used hypoglycemic drug in clinic. It has been found that metformin has anti-inflammatory, anti-tumor and lipid metabolism regulating effects. Basic studies have shown that metformin as an adjuvant drug combined with gabapentin and tramadol is safe and effective in patients with neuropathic pain. Postoperative chronic pain as a common complication has seriously affected the quality of life and mood of patients after surgery.Some studies have shown that chronic pain after partial operation manifests as neuropathic pain. The effect of metformin on chronic pain after thoracic surgery in patients with diabetes mellitus was observed in this experiment, which was compared with patients taking insulin to control blood sugar.
The analgesic mechanism of metformin may include the following aspects:(1)Metformin relieves
neuropathic pain mainly because it can activate adenosine monophosphate-activated protein
kinase (AMPK), which plays a crucial role in pain regulation as an important endogenous
kinase controlling energy metabolism.(2)In addition, metformin can also inhibit ERK signaling
pathway, further inhibit sodium channel, prevent the development of peripheral sensitization
and achieve the effect of relieving neuropathic pain. (3)Metformin has been shown to
alleviate bone cancer pain in rats by reducing STAT3 phosphorylation.Clinical research in
this field is limited to basic research and ethical requirements are rarely reported at home
and abroad. Li Chunye et al. of Jiangsu University designed a clinical trial to compare the
efficacy of metformin and gabapentin combined with tramadol on neuropathic pain. The results
showed that metformin had a better effect.
The incidence of chronic pain after thoracic surgery is higher. Postoperative chronic pain is
a complex pain. The nature and mechanism of chronic pain after thoracic surgery are still
controversial. Some studies have shown that some chronic pain after thoracic surgery
manifests neuropathic pain, the mechanism may be related to surgical incision, nerve injury
caused by trauma and increased pain sensitization. Can metformin alleviate chronic pain after
surgery? The research on this aspect is still blank at present.This study was designed as a
prospective cohort study to observe whether there was a difference in the incidence of
chronic pain after thoracoscopic lobectomy between patients taking metformin and patients
injecting insulin to control blood sugar.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05492669 -
Intravenous Lidocaine on Chronic Pain in Patients Undergoing Hepatectomy
|
Phase 2 |