Ketamine Versus Dexmedetomidine With Local Anesthetic in TAP Block

Postoperative Analgesia Clinical Trial

Official title:

Comparison of the Analgesic Effect of Ketamine Versus Dexmedetomidine Added to Local Anesthetic in TAP Block for Lower Abdominal Cancer Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03060070
• Other study ID #: 321
• Status: Completed
• Phase: Phase 2/Phase 3
• First received: February 17, 2017
• Last updated: July 1, 2017
• Start date: March 10, 2017
• Est. completion date: July 1, 2017

Study information

• Verified date: July 2017
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Comparing the analgesic effects of ketamine and dexmedetomidine when added to local anesthetic in TAP block for postoperative analgesia after lower abdominal cancer surgery.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: July 1, 2017
• Est. primary completion date: June 25, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• All patients ASA I and II to whom abdominal surgery for cancer will be conducted will be included in the study

Exclusion Criteria:

• Coagulopathies

• ASA III or IV, patient refusal, sensitivity to the used drugs

Related Conditions & MeSH terms

• Abdominal Neoplasms
• Lower Abdominal Cancer
• Postoperative Analgesia

Intervention

Drug:
• Ketamine
Ketamine at a dose of 0.5mg/kg will be added to bupivacaine 0.25 (total volume 20ml) in each side using sonar guided TAP block
• dexmedetomidine
dexmedetomidine at a dose of 1ug/kg will be added to bupivacaine 0.25 (total volume 20ml) in each side using sonar guided TAP block
• control group
20ml of 0.25% bupivacaine will be injected in each side of the TAP block

Locations

Country	Name	City	State
Egypt	South Egypt Cancer Institute	Assiut	Assiut University

Sponsors (2)

Lead Sponsor	Collaborator
Assiut University	South Egypt Cancer Institute

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	postoperative rescue morphine consumption	postoperative rescue morphine consumption	24 hours postoperative