Breast Neoplasms Clinical Trial
Official title:
Influence of Vitamin D on Gene Expression Profile of Breast Cancer Samples From Post-menopausal Patients
The purpose of this study is to evaluate whether calcitriol supplementation may reduce tumor cell proliferation and influence gene expression profile of breast cancer samples from post-menopausal patients.
Women affected by breast cancer present lower 1,25(OH)2D3 or 25(OH)D3 serum levels than
unaffected ones. Calcitriol supplementation may be indicated to post-menopausal women to
reduce bone loss. Vitamin D has antiproliferative effects in breast cancer cell lines and
breast cancer xenografts.
Post-menopausal breast cancer patients will be prescribed calcitriol supplementation, in
doses indicated to prevent osteoporosis, while they are submitted to biopsy, staging exams
and have their breast surgery scheduled (approximately one month). Tumor dimension and
proliferation rate (as determined by Ki67 expression), 25(OH)D3 and/or 1,25(OH)2D3 serum
concentration, will be evaluated before and after calcitriol supplementation. Tumor gene
expression will be evaluated in samples collected before and after supplementation to
analyze the differential profile.
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Intervention Model: Single Group Assignment, Masking: Open Label
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