Neuralgia Clinical Trial
Official title:
Effects of Pennsaid on Clinical Neuropathic Pain
The purpose of this study is to see if the drug Pennsaid (Diclofenac) can help reduce pain
felt by people with chronic nerve pain. The drug will be used 2-4 times each day for 2
weeks.
The U.S. Food and Drug Administration (FDA) has approved Pennsaid to treat osteoarthritis
(bone pain), but the FDA has not approved Pennsaid to treat neuropathic (nerve) pain.
The research study will compare Pennsaid to placebo.
The research study will compare Pennsaid to placebo. The placebo looks like Pennsaid, but it
doesn't contain any Pennsaid. The investigators use placebos in research to see if the
results are due to the study drug or to other reasons. At some time during the study the
investigators will give the patient Pennsaid. At another time, the investigators will give
the patient placebo. The investigators are using Quantitative Sensory Testing (QST), which
is temperature testing before and after using the study drug to see if Pennsaid is helpful
in reducing people's nerve pain.
In this test, a small metal plate, about the size of a matchbox, is put on the area where
the patient has pain. The plate is connected to a computer that can warm or cool the plate.
The patient will use a computer mouse button to tell us when the plate feels warm. The QST
machine is approved by the Food and Drug Administration (FDA). It is often used by nerve
doctors to see if a person has neuropathy (pain caused by damage to a nerve).
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
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