Clinical Trials Logo

Clinical Trial Summary

The objective of this study is to provide pain relief to patients with facet joint disease or head and neck pain related to compression of a nerve root. The goal is to provide palliative care with superior efficacy and longer relief compared to current methods.


Clinical Trial Description

Nerve ablation is used therapeutically to produce temporary anesthesia and diagnostically to locate the source of pain. Ablation, or purposeful destruction of tissue, relieves facet joint pain and pain related to nerve damage by disabling pain-transmitting nerves. Cryoablation for pain management is particularly useful when other modalities are too difficult to perform or have a high incidence for complications or side effects. Currently nerve ablation is performed with bupivacaine and alcohol, but MRI-guided cryoablation of nerves and facets may result in superior efficacy and longer relief. Cryotherapy techniques provide long term analgesia and help alleviate intractable pain for patients with facet joint pain and neuralgia. Minimally invasive Magnetic Resonance (MR)-guided ablation of nerves and facets may lead to decreased procedure time and increased relief of pain due to cancer or nerve degeneration. With the advent of the Advanced Multimodality Image Guided Operating Suite (AMIGO) at the Brigham and Women's Hospital, we have exceptional capabilities for minimally invasive image-guided procedures, including different ablation techniques. The AMIGO suite is equipped with hardware that will keep the patient stationary while the Magnetic Resonance Imaging scanner moves to the patient. Additionally, the monitoring software within the AMIGO suite allows clinicians to instantaneously analyze the imaging information which significantly reduces the risk of injury to adjacent structures. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01788410
Study type Observational
Source Brigham and Women's Hospital
Contact Thomas Lee, MD
Phone (617) 732-7260
Email tchlee@partners.org
Status Recruiting
Phase
Start date May 2013
Completion date May 2030

See also
  Status Clinical Trial Phase
Completed NCT03195868 - Photobiomodulation Therapy and Nerve Density for Patients With Diabetic or Chemotherapy-associated Neuropathy N/A
Not yet recruiting NCT05565469 - Correlation Between Abdominal Wall Stimulation and Neurostimulator Tip Location N/A
Completed NCT02309164 - The Use of Acupuncture for Treatment of Chemotherapy-induced Peripheral Neuropathy (CIPN). N/A
Completed NCT00775645 - S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, Stage II, or Stage IIIA Breast Cancer Undergoing Chemotherapy Phase 3
Completed NCT03624426 - Detection and Prevention of Nerve Injury in Shoulder Arthroplasty Surgery N/A
Withdrawn NCT03436680 - Home-Based Neurofeedback Program in Treating Participants With Chemotherapy-Induced Peripheral Neuropathy N/A
Completed NCT05691738 - Effects of Modified Otago Exercises in Individuals With Diabetic Neuropathy N/A
Completed NCT05095870 - Evaluation of the Peripheral Nerve Ultrasound as a Diagnostic Tool in CANVAS Neuropathies
Completed NCT02615678 - Acupuncture for CIPN in Breast Cancer Patients N/A
Completed NCT02011282 - Electro-Neuro-Muscular Stimulation in ICU N/A
Recruiting NCT01774058 - The Arterial Measurement of the Blood Flow Volume After Iloprost Stimulation Phase 2
Completed NCT01135251 - Safety and Preliminary Evidence of Efficacy of Escalating Doses of Dimiracetam in AIDS Patients With Painful Neuropathy Phase 2
Recruiting NCT06324344 - Transcutaneous Electrical Nerve Stimulation (TENS) for Chemotherapy Induced Peripheral Neuropathy (CIPN) N/A
Recruiting NCT04403802 - Voxx Human Performance Technology Socks for Chemotherapy-Induced Peripheral Neuropathy N/A
Recruiting NCT04579406 - Perioperative Adverse Cardiovascular Event in Type-2 Diabetic Patients
Recruiting NCT03881930 - Balance Rehabilitation With Modified Visual Input in Patients With Neuropathy N/A
Completed NCT03909464 - Non-Invasive Neurosensory Testing For Chemotherapy-Induced Peripheral Neuropathy
Completed NCT01523132 - Persistent Pain After Breast Cancer Treatment (PPBCT) - Risk Factors and Pathophysiological Mechanisms N/A
Completed NCT02689661 - Impact of the Metabolic Syndrome on the Incidence of Neuropathy in Obese Subjects
Terminated NCT00998738 - Calcium and Magnesium in Preventing Peripheral Neuropathy Caused by Ixabepilone in Patients With Breast Cancer Phase 3