Posterior Capsule Opacification After Lens Capsule Polishing

Status Recruiting

Clinical Trial Summary

Investigate the effect of polishing of the lens capsule during cataract surgery on the development of posterior capsule opacification

Clinical Trial Description

Cataract, the clouding if the eye's lens, is the leading cause of blindness worldwide, with phacoemulsification and implantation of an intraocular lens being the only therapeutic option. Cataract surgery is nowadays considered a safe and efficient procedure. However, one of the most frequent complications after surgery is posterior capsule opacification (PCO), that results in diminished postoperative visual acuity. PCO occurs due to remaining lens epithelial cells in the capsular bag, that start to migrate and proliferate.

PCO can be easily treated by performing a neodymium-doped yttrium aluminium garnet (Nd-YAG) laser capsulotomy. However, even if laser capsulotomy is considered a simple procedure, possible complications are rise of intraocular pressure, inflammation, cystoid macular edema, or retinal detachment. Furthermore, several patients are no suitable candidates for laser capsulotomy, for example children and patients with high myopia.

Therefore, it would be necessery to identify different approaches to prevent generation of PCO. One approach could be "cleaning" of the lens epithelial cells in the capsular bag by polishing of the lens capsule during surgery. Hence, the aim of this study is to examine whether capsular polishing is beneficial to decrease the growth and proliferation of LECs. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03857412
Study type	Interventional
Source	Vienna Institute for Research in Ocular Surgery
Contact	Andreea Fisus, MD
Phone	01 91021-57564
Email	office@viros.at
Status	Recruiting
Phase	N/A
Start date	February 13, 2019
Completion date	February 1, 2021

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