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Clinical Trial Summary

The goal of this study is to develop and test a novel pathophysiology of PTSD by integrating sensory cortical (SC) and amygdala-PFC dysfunctions into a tripartite Sensory-Prefrontal-Cortex-Amygdala (SPA) model.


Clinical Trial Description

This study includes Expt. 1a & Expt. 1b to address Aims 1& 2--intrinsic and novelty-related SC disinhibition and SPA pathology in PTSD. The investigators will recruit 80 healthy subjects and 80 patients with PTS randomized, double-blind, controlled design, where tACS will be delivered at individual alpha peak frequency (active condition) and random frequency (1-200 Hz; random noise stimulation/RNS; active control condition), randomly assigned across subjects in each group. Simultaneous EEG- fMRI recordings during the resting state (Expt. 1a) and during the novelty task (Expt. 1b) will be acquired before and after tACS/RNS. During tACS/RNS, stimulation electrodes will be placed inside the holders of the BrainProducts EEG cap attached to the head of the participant. A very weak (completely tolerable and often unnoticeable) electrical current will be applied to the scalp via the stimulation electrodes. Overall, this study will take a basic neuroscience approach to investigate pathological mechanisms underlying PTSD ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05895006
Study type Interventional
Source Florida State University
Contact Wen Li, PhD
Phone 850-645-1409
Email wenli@psy.fsu.edu
Status Recruiting
Phase N/A
Start date January 1, 2023
Completion date October 2027

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