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Clinical Trial Summary

This study will enroll patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for post-traumatic stress disorder (PTSD). Following an initial screening visit, clinical assessment, and enrollment, subjects will be randomized into treatment and placebo arms. Both cohorts will undergo a pre-intervention functional magnetic resonance imaging (fMRI) of their brain. Treatment subjects will receive unilateral two-level stellate ganglion block via ultrasound-guided injection of anesthetic (bupivacaine) into the cervical sympathetic tissue; placebo subjects will receive an identical volume of saline via the same procedures. At approximately 4 weeks post-procedure, both cohorts will then undergo a post-intervention clinical assessment. Finally, both cohorts will undergo a post-intervention fMRI of their brain.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05391971
Study type Interventional
Source NYU Langone Health
Contact Paul Glimcher, PhD
Phone 212-263-8169
Email Paul.Glimcher@nyulangone.org
Status Recruiting
Phase Phase 4
Start date August 1, 2022
Completion date August 15, 2025

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