Effects of Stellate Ganglion Block in Post-traumatic Stress Disorder

Status Recruiting

Clinical Trial Summary

This study will enroll patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for post-traumatic stress disorder (PTSD). Following an initial screening visit, clinical assessment, and enrollment, subjects will be randomized into treatment and placebo arms. Both cohorts will undergo a pre-intervention functional magnetic resonance imaging (fMRI) of their brain. Treatment subjects will receive unilateral two-level stellate ganglion block via ultrasound-guided injection of anesthetic (bupivacaine) into the cervical sympathetic tissue; placebo subjects will receive an identical volume of saline via the same procedures. At approximately 4 weeks post-procedure, both cohorts will then undergo a post-intervention clinical assessment. Finally, both cohorts will undergo a post-intervention fMRI of their brain.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05391971
Study type	Interventional
Source	NYU Langone Health
Contact	Paul Glimcher, PhD
Phone	212-263-8169
Email	Paul.Glimcher@nyulangone.org
Status	Recruiting
Phase	Phase 4
Start date	August 1, 2022
Completion date	August 15, 2025

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