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Combined Ketamine and eCBT Intervention for PTSD

Post-Traumatic Stress Disorder Clinical Trial

Official title:
Assessing a Combined Ketamine and Online Cognitive Behavioural Therapy Intervention for Treatment Resistant Post-Traumatic Stress Disorder

Clinical Trial Summary

An open label RCT assessing the efficacy of a combined treatment approach for PTSD, using Ketamine infusions and online Cognitive Behavioural Therapy.

Clinical Trial Description

OBJECTIVES (i) To introduce a previously untreated patient population with PTSD to new therapeutic options. (ii) To provide new insights into the functional role of Glutamate in affective disorders as well as in learning and memory. (iii) To explore the utility of pharmacologically-enhanced psychotherapy. OUTLINE The present study is an open label randomized control trial assessing the efficacy of a combined treatment of sub-anaesthetic IV Ketamine in conjunction with online CBT (eCBT). In the study, 16 participants with refractory PTSD will be assigned either to an experimental group receiving a combination of Ketamine and eCBT over 12 weeks, or they will be assigned to a 12-week control group. Both groups will be assessed for symptoms of PTSD and comorbid disorders before treatment, at 2 midway points (4 and 8 weeks), and at the end of the 12 week experimental period. Symptoms of PTSD and comorbid disorders for participants in the experimental group are expected to improve significantly more than participants in the control. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04771767
Study type Interventional
Source Queen's University
Contact Aaron E Philipp-Muller, B.Sc.
Phone 416-939-3164
Email 19aepm1@queensu.ca
Status Recruiting
Phase Phase 2
Start date August 1, 2021
Completion date March 31, 2024
View Details
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